This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5h1i
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5h1i is ON HOLD Authors: Xiao, T., Tam, J.P. Description: NMR structure of TIBA, a chimera of SFTI Category: Unreleased Structures [[Category: ...) |
|||
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==NMR structure of TIBA, a chimera of SFTI== | |
| + | <StructureSection load='5h1i' size='340' side='right'caption='[[5h1i]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5h1i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helianthus_annuus Helianthus annuus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H1I FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h1i OCA], [https://pdbe.org/5h1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h1i RCSB], [https://www.ebi.ac.uk/pdbsum/5h1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h1i ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | An orally active and metabolically stable peptide TIBA was successfully engineered as a chimera by fusing an analgesic bradykinin receptor antagonist peptide and the trypsin inhibitory loop of sunflower trypsin inhibitor-1. As a fusion cyclic peptide, the metabolically labile analgesic peptide is protected from degradation by exopeptidases as well as the endopeptidases, and its serum half-life extended from <5 min to >6 h as a chimera. Moreover, the chimera TIBA was also found to be orally active in an animal pain model using a hot plate assay. | ||
| - | + | An Orally Active Bradykinin B1 Receptor Antagonist Engineered as a Bifunctional Chimera of Sunflower Trypsin Inhibitor.,Qiu Y, Taichi M, Wei N, Yang H, Luo KQ, Tam JP J Med Chem. 2017 Jan 12;60(1):504-510. doi: 10.1021/acs.jmedchem.6b01011. Epub, 2016 Dec 15. PMID:27977181<ref>PMID:27977181</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5h1i" style="background-color:#fffaf0;"></div> |
| - | [[Category: Tam | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Helianthus annuus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Tam JP]] | ||
| + | [[Category: Xiao T]] | ||
Current revision
NMR structure of TIBA, a chimera of SFTI
| |||||||||||
