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5nf8

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==Solution structure of detergent-solubilized Rcf1, a yeast mitochondrial inner membrane protein involved in respiratory Complex III/IV supercomplex formation==
==Solution structure of detergent-solubilized Rcf1, a yeast mitochondrial inner membrane protein involved in respiratory Complex III/IV supercomplex formation==
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<StructureSection load='5nf8' size='340' side='right' caption='[[5nf8]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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<StructureSection load='5nf8' size='340' side='right'caption='[[5nf8]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5nf8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NF8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NF8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5nf8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NF8 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RCF1, AIM31, SCRG_01865 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nf8 OCA], [https://pdbe.org/5nf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nf8 RCSB], [https://www.ebi.ac.uk/pdbsum/5nf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nf8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nf8 OCA], [http://pdbe.org/5nf8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nf8 RCSB], [http://www.ebi.ac.uk/pdbsum/5nf8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nf8 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RCF1_YEAS1 RCF1_YEAS1]] Cytochrome c oxidase subunit required for growth under hypoxic conditions. Involved in the assembly of the Complex III-Complex IV supercomplex, as well as in the recruitment of COX13 and RCF2 into cytochrome c oxidase. May also be required for late-stage assembly of the COX12 and COX13 subunits and for cytochrome c oxidase activity (By similarity).
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[https://www.uniprot.org/uniprot/RCF1_YEAST RCF1_YEAST] Assembly factor that plays a role in the assembly of the respiratory chain supercomplexes (SCs) composed of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV). Involved in the recruitment of COX13 and RCF2 into cytochrome c oxidase. May also be required for late-stage assembly of the COX12 and COX13 subunits (PubMed:22342701, PubMed:22405070, PubMed:22310663). Required for the generation and maintenance of a normal proton motive force (PMF) across the inner mitochondrial membrane (IMM) by preventing proton leakage through an inactive population of CIV that accumulates when RCF1 and/or RCF2 proteins are absent (PubMed:30683696, PubMed:31591265).<ref>PMID:22310663</ref> <ref>PMID:22342701</ref> <ref>PMID:22405070</ref> <ref>PMID:30683696</ref> <ref>PMID:31591265</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 18824]]
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[[Category: Large Structures]]
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[[Category: Adelroth, P]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Brzezinski, P]]
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[[Category: Adelroth P]]
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[[Category: Hogbom, M]]
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[[Category: Brzezinski P]]
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[[Category: Maler, L]]
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[[Category: Hogbom M]]
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[[Category: Pettersson, P]]
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[[Category: Maler L]]
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[[Category: Sjoholm, J]]
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[[Category: Pettersson P]]
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[[Category: Sjostrand, D]]
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[[Category: Sjoholm J]]
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[[Category: Zhou, S]]
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[[Category: Sjostrand D]]
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[[Category: Charged dimer interface]]
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[[Category: Zhou S]]
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[[Category: Homodimer]]
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[[Category: Membrane protein]]
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[[Category: Solution structure]]
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Current revision

Solution structure of detergent-solubilized Rcf1, a yeast mitochondrial inner membrane protein involved in respiratory Complex III/IV supercomplex formation

PDB ID 5nf8

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