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5o57

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Current revision (10:22, 14 June 2023) (edit) (undo)
 
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==Solution Structure of the N-terminal Region of Dkk4==
==Solution Structure of the N-terminal Region of Dkk4==
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<StructureSection load='5o57' size='340' side='right'caption='[[5o57]], [[NMR_Ensembles_of_Models | 70 NMR models]]' scene=''>
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<StructureSection load='5o57' size='340' side='right'caption='[[5o57]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5o57]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O57 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O57 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5o57]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5O57 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DKK4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5o57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o57 OCA], [https://pdbe.org/5o57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5o57 RCSB], [https://www.ebi.ac.uk/pdbsum/5o57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5o57 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o57 OCA], [http://pdbe.org/5o57 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o57 RCSB], [http://www.ebi.ac.uk/pdbsum/5o57 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o57 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DKK4_HUMAN DKK4_HUMAN]] Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
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[https://www.uniprot.org/uniprot/DKK4_HUMAN DKK4_HUMAN] Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Barkell, A M]]
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[[Category: Barkell AM]]
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[[Category: Carr, M D]]
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[[Category: Carr MD]]
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[[Category: Holdsworth, G]]
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[[Category: Holdsworth G]]
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[[Category: Muskett, F W]]
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[[Category: Muskett FW]]
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[[Category: Patel, S]]
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[[Category: Patel S]]
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[[Category: Robinson, M K]]
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[[Category: Robinson MK]]
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[[Category: Waters, L C]]
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[[Category: Waters LC]]
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[[Category: Cysteine-rich domain 1]]
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[[Category: Dkk4]]
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[[Category: Signaling protein]]
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[[Category: Wnt signalling]]
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Current revision

Solution Structure of the N-terminal Region of Dkk4

PDB ID 5o57

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