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5o9b
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==Solution NMR structure of human GATA2 C-terminal zinc finger domain== | ==Solution NMR structure of human GATA2 C-terminal zinc finger domain== | ||
| - | <StructureSection load='5o9b' size='340' side='right'caption='[[5o9b | + | <StructureSection load='5o9b' size='340' side='right'caption='[[5o9b]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5o9b]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5o9b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5O9B FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5o9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o9b OCA], [https://pdbe.org/5o9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5o9b RCSB], [https://www.ebi.ac.uk/pdbsum/5o9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5o9b ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/GATA2_HUMAN GATA2_HUMAN] Deafness-lymphedema-leukemia syndrome;Inherited acute myeloid leukemia;Myelodysplastic syndrome;Monocytopenia with susceptibility to infections. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/GATA2_HUMAN GATA2_HUMAN] Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Broadhurst | + | [[Category: Broadhurst RW]] |
| - | [[Category: Enver | + | [[Category: Enver T]] |
| - | [[Category: May | + | [[Category: May G]] |
| - | [[Category: Nurmohamed | + | [[Category: Nurmohamed SS]] |
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Current revision
Solution NMR structure of human GATA2 C-terminal zinc finger domain
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