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6ccw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Hybrid-2 form Human Telomeric G Quadruplex in Complex with Epiberberine== | |
| + | <StructureSection load='6ccw' size='340' side='right'caption='[[6ccw]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6ccw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CCW FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EWV:Epiberberine'>EWV</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ccw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ccw OCA], [https://pdbe.org/6ccw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ccw RCSB], [https://www.ebi.ac.uk/pdbsum/6ccw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ccw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Human telomeres can form DNA G-quadruplex (G4), an attractive target for anticancer drugs. Human telomeric G4s bear inherent structure polymorphism, challenging for understanding specific recognition by ligands or proteins. Protoberberines are medicinal natural-products known to stabilize telomeric G4s and inhibit telomerase. Here we report epiberberine (EPI) specifically recognizes the hybrid-2 telomeric G4 predominant in physiologically relevant K+ solution and converts other telomeric G4 forms to hybrid-2, the first such example. Our NMR structure in K+ solution shows EPI binding induces extensive rearrangement of the previously disordered 5' flanking and loop segments to form an unprecedented four-layer binding pocket specific to the hybrid-2 telomeric G4; EPI recruits the -1 adenine to form a "quasi-triad" intercalated between the external tetrad and a T:T:A triad, capped by a T:T base-pair. Our study provides structural basis for small-molecule drug design targeting the human telomeric G4. | ||
| - | + | Molecular Recognition of the Hybrid-2 Human Telomeric G-quadruplex by Epiberberine: Insights into Conversion of Telomeric G-quadruplex Structures.,Lin C, Wu G, Wang K, Onel B, Sakai S, Shao Y, Yang D Angew Chem Int Ed Engl. 2018 Jun 10. doi: 10.1002/anie.201804667. PMID:29888501<ref>PMID:29888501</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Lin | + | <div class="pdbe-citations 6ccw" style="background-color:#fffaf0;"></div> |
| - | [[Category: Yang | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lin C]] | ||
| + | [[Category: Yang DZ]] | ||
Current revision
Hybrid-2 form Human Telomeric G Quadruplex in Complex with Epiberberine
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