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6d8h
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==NMR solution structure of tamapin, mutant Y31+N== | ==NMR solution structure of tamapin, mutant Y31+N== | ||
| - | <StructureSection load='6d8h' size='340' side='right'caption='[[6d8h | + | <StructureSection load='6d8h' size='340' side='right'caption='[[6d8h]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6d8h]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D8H OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6d8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_tamulus Mesobuthus tamulus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D8H FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d8h OCA], [https://pdbe.org/6d8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d8h RCSB], [https://www.ebi.ac.uk/pdbsum/6d8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d8h ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/KAX54_HOTTA KAX54_HOTTA] Blocks small conductance calcium-activated potassium channels (PubMed:12239213). Shows activity on KCa2.2/KCNN2 (IC(50)=0.0243 nM), KCa2.3/KCNN3 (IC(50)=1.7 nM), and KCa2.1/KCNN1 (IC(50)=42 nM) (PubMed:12239213). Induces cell death when tested on Jurkat E6-1 and human mammary breast cancer MDA-MB-231 which constituvely express KCa2.2/KCNN2, but not on human peripheral blood lymphocytes (which do not express KCa2.2/KCNN2) (PubMed:24821061).<ref>PMID:12239213</ref> |
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| + | ==See Also== | ||
| + | *[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mesobuthus tamulus]] |
| - | [[Category: Flores | + | [[Category: Mayorga Flores M]] |
| - | [[Category: Meneses | + | [[Category: Melchor Meneses CM]] |
| - | [[Category: | + | [[Category: Titaux Delgado GA]] |
| - | [[Category: | + | [[Category: Del Rio Portilla F]] |
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Current revision
NMR solution structure of tamapin, mutant Y31+N
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