This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6hpi
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6hpi is ON HOLD Authors: Ohlenschlaeger, O., Imhof, D. Description: NMR structure of the pro-inflammatory cytokine interleukin-36alpha [[Category: ...) |
|||
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==NMR structure of the pro-inflammatory cytokine interleukin-36alpha== | |
| + | <StructureSection load='6hpi' size='340' side='right'caption='[[6hpi]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6hpi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HPI FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hpi OCA], [https://pdbe.org/6hpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hpi RCSB], [https://www.ebi.ac.uk/pdbsum/6hpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hpi ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IL36A_HUMAN IL36A_HUMAN] Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung.<ref>PMID:14734551</ref> <ref>PMID:21881584</ref> <ref>PMID:21965679</ref> <ref>PMID:24829417</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Interleukin-36alpha (IL-36alpha) is a recently characterised member of the interleukin-1 superfamily. It is involved in the pathogenesis of inflammatory arthritis in one third of psoriasis patients. By binding of IL-36alpha to its receptor IL-36R via the NF-kappaB pathway other cytokines involved in inflammatory and apoptotic cascade are activated. The efficacy of complex formation is controlled by N-terminal processing. To obtain a more detailed view on the structure function relationship we performed a heteronuclear multidimensional NMR investigation and here report the (1)H, (13)C, and (15)N resonance assignments for the backbone and side chain nuclei of the pro-inflammatory cytokine interleukin-36alpha. | ||
| - | + | (1)H, (13)C, and (15)N resonance assignments for the pro-inflammatory cytokine interleukin-36alpha.,Goradia N, Wissbrock A, Wiedemann C, Bordusa F, Ramachandran R, Imhof D, Ohlenschlager O Biomol NMR Assign. 2016 Oct;10(2):329-33. doi: 10.1007/s12104-016-9694-7. Epub , 2016 Jun 28. PMID:27351892<ref>PMID:27351892</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Imhof | + | <div class="pdbe-citations 6hpi" style="background-color:#fffaf0;"></div> |
| - | [[Category: Ohlenschlaeger | + | |
| + | ==See Also== | ||
| + | *[[Interleukin 3D structures|Interleukin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Imhof D]] | ||
| + | [[Category: Ohlenschlaeger O]] | ||
Current revision
NMR structure of the pro-inflammatory cytokine interleukin-36alpha
| |||||||||||
