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| | ==An order-to-disorder structural switch activates the FoxM1 transcription factor== | | ==An order-to-disorder structural switch activates the FoxM1 transcription factor== |
| - | <StructureSection load='6osw' size='340' side='right'caption='[[6osw]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | + | <StructureSection load='6osw' size='340' side='right'caption='[[6osw]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6osw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OSW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OSW FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6osw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OSW FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">foxm1, foxm1l ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6osw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6osw OCA], [https://pdbe.org/6osw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6osw RCSB], [https://www.ebi.ac.uk/pdbsum/6osw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6osw ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6osw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6osw OCA], [http://pdbe.org/6osw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6osw RCSB], [http://www.ebi.ac.uk/pdbsum/6osw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6osw ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q7T2G3_DANRE Q7T2G3_DANRE] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </div> | | </div> |
| | <div class="pdbe-citations 6osw" style="background-color:#fffaf0;"></div> | | <div class="pdbe-citations 6osw" style="background-color:#fffaf0;"></div> |
| | + | |
| | + | ==See Also== |
| | + | *[[FOX 3D structures|FOX 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Brachidanio rerio]] | + | [[Category: Danio rerio]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Marceau, A H]] | + | [[Category: Marceau AH]] |
| - | [[Category: McShane, A C]] | + | [[Category: McShane AC]] |
| - | [[Category: Nerli, S]] | + | [[Category: Nerli S]] |
| - | [[Category: Rubin, S M]] | + | [[Category: Rubin SM]] |
| - | [[Category: Sgourakis, N G]] | + | [[Category: Sgourakis NG]] |
| - | [[Category: Cell cycle]]
| + | |
| - | [[Category: Negative regulatory domain]]
| + | |
| - | [[Category: Transactivation domain]]
| + | |
| - | [[Category: Transcription factor]]
| + | |
| Structural highlights
Function
Q7T2G3_DANRE
Publication Abstract from PubMed
Intrinsically disordered transcription factor transactivation domains (TADs) function through structural plasticity, adopting ordered conformations when bound to transcriptional co-regulators. Many transcription factors contain a negative regulatory domain (NRD) that suppresses recruitment of transcriptional machinery through autoregulation of the TAD. We report the solution structure of an autoinhibited NRD-TAD complex within FoxM1, a critical activator of mitotic gene expression. We observe that while both the FoxM1 NRD and TAD are primarily intrinsically disordered domains, they associate and adopt a structured conformation. We identify how Plk1 and Cdk kinases cooperate to phosphorylate FoxM1, which releases the TAD into a disordered conformation that then associates with the TAZ2 or KIX domains of the transcriptional co-activator CBP. Our results support a mechanism of FoxM1 regulation in which the TAD undergoes switching between disordered and different ordered structures.
An order-to-disorder structural switch activates the FoxM1 transcription factor.,Marceau AH, Brison CM, Nerli S, Arsenault HE, McShan AC, Chen E, Lee HW, Benanti JA, Sgourakis NG, Rubin SM Elife. 2019 May 28;8. pii: 46131. doi: 10.7554/eLife.46131. PMID:31134895[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Marceau AH, Brison CM, Nerli S, Arsenault HE, McShan AC, Chen E, Lee HW, Benanti JA, Sgourakis NG, Rubin SM. An order-to-disorder structural switch activates the FoxM1 transcription factor. Elife. 2019 May 28;8. pii: 46131. doi: 10.7554/eLife.46131. PMID:31134895 doi:http://dx.doi.org/10.7554/eLife.46131
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