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6svc

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==Protein allostery of the WW domain at atomic resolution: apo structure==
==Protein allostery of the WW domain at atomic resolution: apo structure==
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<StructureSection load='6svc' size='340' side='right'caption='[[6svc]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='6svc' size='340' side='right'caption='[[6svc]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6svc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SVC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SVC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6svc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SVC FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6svh|6svh]], [[6sve|6sve]]</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6svc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6svc OCA], [https://pdbe.org/6svc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6svc RCSB], [https://www.ebi.ac.uk/pdbsum/6svc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6svc ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6svc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6svc OCA], [http://pdbe.org/6svc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6svc RCSB], [http://www.ebi.ac.uk/pdbsum/6svc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6svc ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN]] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
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[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Friedmann M]]
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[[Category: Friedmann, M]]
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[[Category: Guntert P]]
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[[Category: Guntert, P]]
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[[Category: Orts J]]
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[[Category: Orts, J]]
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[[Category: Riek R]]
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[[Category: Riek, R]]
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[[Category: Strotz D]]
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[[Category: Strotz, D]]
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[[Category: Vogeli B]]
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[[Category: Vogeli, B]]
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[[Category: Peptide binding protein]]
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[[Category: Structure from cyana 3 98 12]]
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Current revision

Protein allostery of the WW domain at atomic resolution: apo structure

PDB ID 6svc

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