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6zx6
From Proteopedia
(Difference between revisions)
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<StructureSection load='6zx6' size='340' side='right'caption='[[6zx6]]' scene=''> | <StructureSection load='6zx6' size='340' side='right'caption='[[6zx6]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[6zx6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZX6 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zx6 OCA], [https://pdbe.org/6zx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zx6 RCSB], [https://www.ebi.ac.uk/pdbsum/6zx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zx6 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zx6 OCA], [https://pdbe.org/6zx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zx6 RCSB], [https://www.ebi.ac.uk/pdbsum/6zx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zx6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Misregulation of BCL2 expression has been observed with many diseases and is associated with cellular exposure to reactive oxygen species. A region upstream of the P1 promoter in the human BCL2 gene plays a major role in regulating transcription. This G/C-rich region is highly polymorphic and capable of forming G-quadruplex structures. Herein we report that an oxidative event simulated with an 8-oxo-7,8-dihydroguanine (oxoG) substitution within a long G-tract results in a reduction of structural polymorphism. Surprisingly, oxoG within a 25-nt construct boosts thermal stability of the resulting G-quadruplex. This is achieved by distinct hydrogen bonding properties of oxoG, which facilitate formation of an antiparallel basket-type G-quadruplex with a three G-quartet core and a G.oxoG.C base triad. While oxoG has previously been considered detrimental for G-quadruplex formation, its stabilizing effect within a promoter described in this study suggests a potential novel regulatory role of oxidative stress in general and specifically in BCL2 gene transcription. | ||
| + | |||
| + | Oxidative lesions modulate G-quadruplex stability and structure in the human BCL2 promoter.,Bielskute S, Plavec J, Podbevsek P Nucleic Acids Res. 2021 Feb 26;49(4):2346-2356. doi: 10.1093/nar/gkab057. PMID:33638996<ref>PMID:33638996</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6zx6" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bielskute S]] | [[Category: Bielskute S]] | ||
[[Category: Plavec J]] | [[Category: Plavec J]] | ||
[[Category: Podbevsek P]] | [[Category: Podbevsek P]] | ||
Current revision
Antiparallel basket-type G-quadruplex DNA structure formed in human Bcl-2 promoter containing 8-oxoG
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