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5civ

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Sibling Lethal Factor Precursor - DfsB

Structural highlights

5civ is a 1 chain structure with sequence from Paenibacillus dendritiformis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

D0EVD3_9BACL

Publication Abstract from PubMed

Bacteria have developed a variety of mechanisms for surviving harsh environmental conditions, nutrient stress and overpopulation. Paenibacillus dendritiformis produces a lethal protein (Slf) that is able to induce cell death in neighbouring colonies and a phenotypic switch in more distant ones. Slf is derived from the secreted precursor protein, DfsB, after proteolytic processing. Here, we present new crystal structures of DfsB homologues from a variety of bacterial species and a surprising version present in the yeast Saccharomyces cerevisiae. Adopting a four-helix bundle decorated with a further three short helices within intervening loops, DfsB belongs to a non-enzymatic class of the DinB fold. The structure suggests that the biologically active Slf fragment may possess a C-terminal helix rich in basic and aromatic residues that suggest a functional mechanism akin to that for cationic antimicrobial peptides.

Structures of the DfsB Protein Family Suggest a Cationic, Helical Sibling Lethal Factor Peptide.,Taylor JD, Taylor G, Hare SA, Matthews SJ J Mol Biol. 2016 Jan 21. pii: S0022-2836(16)00032-2. doi:, 10.1016/j.jmb.2016.01.013. PMID:26804569^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Taylor JD, Taylor G, Hare SA, Matthews SJ. Structures of the DfsB Protein Family Suggest a Cationic, Helical Sibling Lethal Factor Peptide. J Mol Biol. 2016 Jan 21. pii: S0022-2836(16)00032-2. doi:, 10.1016/j.jmb.2016.01.013. PMID:26804569 doi:http://dx.doi.org/10.1016/j.jmb.2016.01.013

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5civ"

Categories: Large Structures | Paenibacillus dendritiformis | Matthews SJ | Taylor JD

@@ Line 3: / Line 3: @@
 <StructureSection load='5civ' size='340' side='right'caption='[[5civ]], [[Resolution|resolution]] 1.38&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5civ]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bgsc_30a1 Bgsc 30a1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CIV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CIV FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5civ]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Paenibacillus_dendritiformis Paenibacillus dendritiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CIV FirstGlance]. <br>
-</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dfsB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=130049 BGSC 30A1])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5civ FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5civ OCA], [https://pdbe.org/5civ PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5civ RCSB], [https://www.ebi.ac.uk/pdbsum/5civ PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5civ ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5civ FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5civ OCA], [http://pdbe.org/5civ PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5civ RCSB], [http://www.ebi.ac.uk/pdbsum/5civ PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5civ ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/D0EVD3_9BACL D0EVD3_9BACL]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 22: @@
 __TOC__
 </StructureSection>
-[[Category: Bgsc 30a1]]
 [[Category: Large Structures]]
-[[Category: Matthews, S J]]
+[[Category: Paenibacillus dendritiformis]]
-[[Category: Taylor, J D]]
+[[Category: Matthews SJ]]
-[[Category: Bacteriocin]]
+[[Category: Taylor JD]]
-[[Category: Cell cycle]]
-[[Category: Duf1706]]
-[[Category: Sporulation]]
-[[Category: Unknown function]]

5civ

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Current revision

Sibling Lethal Factor Precursor - DfsB

Structural highlights

Function

Publication Abstract from PubMed

References

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