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5cnj

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==mGlur2 with glutamate analog==
==mGlur2 with glutamate analog==
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<StructureSection load='5cnj' size='340' side='right' caption='[[5cnj]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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<StructureSection load='5cnj' size='340' side='right'caption='[[5cnj]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5cnj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CNJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CNJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5cnj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CNJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CNJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=52Q:(1R,2S,4R,5R,6R)-2-AMINO-4-(1H-1,2,4-TRIAZOL-3-YLSULFANYL)BICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC+ACID'>52Q</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=52Q:(1R,2S,4R,5R,6R)-2-AMINO-4-(1H-1,2,4-TRIAZOL-3-YLSULFANYL)BICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC+ACID'>52Q</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cni|5cni]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cnj OCA], [https://pdbe.org/5cnj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cnj RCSB], [https://www.ebi.ac.uk/pdbsum/5cnj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cnj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cnj OCA], [http://pdbe.org/5cnj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cnj RCSB], [http://www.ebi.ac.uk/pdbsum/5cnj PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GRM2_HUMAN GRM2_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.<ref>PMID:18297054</ref> <ref>PMID:22300836</ref> <ref>PMID:23129762</ref> <ref>PMID:7620613</ref>
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[https://www.uniprot.org/uniprot/GRM2_HUMAN GRM2_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.<ref>PMID:18297054</ref> <ref>PMID:22300836</ref> <ref>PMID:23129762</ref> <ref>PMID:7620613</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5cnj" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5cnj" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Metabotropic glutamate receptor 3D structures|Metabotropic glutamate receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Clawson, D K]]
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[[Category: Homo sapiens]]
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[[Category: Monn, J A]]
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[[Category: Large Structures]]
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[[Category: Glutamate receptor analog]]
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[[Category: Clawson DK]]
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[[Category: Signaling protein]]
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[[Category: Monn JA]]

Current revision

mGlur2 with glutamate analog

PDB ID 5cnj

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