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Lactate dehydrogenase 3D structures

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(New page: ==3D structures of lactate dehydrogenase== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *L-LDH **4l4r, [[4o...)
Current revision (07:31, 15 June 2023) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 6: Line 6:
*L-LDH
*L-LDH
-
**[[4l4r]], [[4ojn]] – hLDH A chain – human<br />
+
**[[4l4r]], [[4ojn]], [[6zzr]] – hLDH A chain – human<br />
**[[2ldx]] – C4-LDH - mouse<br />
**[[2ldx]] – C4-LDH - mouse<br />
**[[5k0z]] – LDH B chain – chicken<br />
**[[5k0z]] – LDH B chain – chicken<br />
 +
**[[1ldm]], [[6ldh]], [[8ldh]] – sdM4-LDH – spiny dogfish<BR />
**[[2e37]], [[2v6m]] – TtL-LDH – ''Thermus thermophilus''<BR />
**[[2e37]], [[2v6m]] – TtL-LDH – ''Thermus thermophilus''<BR />
**[[3zzn]], [[4a73]]– TtL-LDH (mutant) <BR />
**[[3zzn]], [[4a73]]– TtL-LDH (mutant) <BR />
**[[2x8l]], [[1ceq]] – PfL-LDH – ''Plasmodium falciparum''<BR />
**[[2x8l]], [[1ceq]] – PfL-LDH – ''Plasmodium falciparum''<BR />
-
**[[2zqy]], [[2zqz]], [[1llc]] – LcL-LDH – ''Lactobacillus casei''<BR />
+
**[[2zqy]], [[2zqz]], [[1llc]], [[6jml]] – LcL-LDH – ''Lactobacillus casei''<BR />
**[[6j9s]] - LcL-LDH (mutant)<br />
**[[6j9s]] - LcL-LDH (mutant)<br />
**[[3d0o]] - SaL-LDH – ''Staphylococcus aureus''<BR />
**[[3d0o]] - SaL-LDH – ''Staphylococcus aureus''<BR />
Line 22: Line 23:
**[[1y6j]] – L-LDH – ''Clostridium thermocellum''<BR />
**[[1y6j]] – L-LDH – ''Clostridium thermocellum''<BR />
**[[1ldb]] - GsL-LDH – ''Geobacillus stearothermophilus''<BR />
**[[1ldb]] - GsL-LDH – ''Geobacillus stearothermophilus''<BR />
-
**[[1ldm]], [[6ldh]], [[8ldh]] – sdM4-LDH – spiny dogfish<BR />
 
**[[4m1q]] - BseL-LDH – ''Bacillus selenitireducens''<br />
**[[4m1q]] - BseL-LDH – ''Bacillus selenitireducens''<br />
**[[3pqe]] – BsL-LDH (mutant) – ''Bacillus subtilis''<br />
**[[3pqe]] – BsL-LDH (mutant) – ''Bacillus subtilis''<br />
Line 30: Line 30:
**[[4uum]] – TvL-LDH – ''Trichomonas vaginalis''<br />
**[[4uum]] – TvL-LDH – ''Trichomonas vaginalis''<br />
**[[4uul]] – TvL-LDH (mutant)<br />
**[[4uul]] – TvL-LDH (mutant)<br />
-
**[[5hs4]] - PvL-LDH – ''Plasmodium vivax''<br />
+
**[[5hs4]], [[6txr]] - PvL-LDH – ''Plasmodium vivax''<br />
**[[6or9]] – LDH – ''Trichoplusia''<br />
**[[6or9]] – LDH – ''Trichoplusia''<br />
 +
**[[7w8a]] – LDH – ''Babesia orientalis''<br />
**[[6k12]] – BmLDH – ''Babesia microti''<br />
**[[6k12]] – BmLDH – ''Babesia microti''<br />
**[[6j9d]] – BmLDH (mutant)<br />
**[[6j9d]] – BmLDH (mutant)<br />
 +
**[[6vdh]], [[6vdi]] – ApLDH - ''Apicomplexa''<br />
 +
**[[8ab2]] – CaL-LDH – ''Cyanobacterium aponium''<br />
 +
**[[7wn9]] – DdLDH – ''Dictyostelium discoideum''<br />
*L-LDH from yeast (cytochrome b2)
*L-LDH from yeast (cytochrome b2)
Line 46: Line 50:
*''L-LDH binary complex''
*''L-LDH binary complex''
-
**[[4ajp]], [[4m49]], [[4qsm]], [[4qt0]], [[5w8h]], [[5w8i]], [[5w8j]] – hLDH A chain + inhibitor <br />
+
**[[4ajp]], [[4m49]], [[4qsm]], [[4qt0]], [[5w8h]], [[5w8i]], [[5w8j]], [[6q13]], [[6sbv]] – hLDH A chain + inhibitor <br />
-
**[[4l4s]] – hLDH α chain + NAD <br />
+
**[[4l4s]] – hLDH A chain + NAD <br />
**[[5zje]] - hL-LDH A chain + malonate <br />
**[[5zje]] - hL-LDH A chain + malonate <br />
**[[5zjf]] - hL-LDH A chain + machilin<br />
**[[5zjf]] - hL-LDH A chain + machilin<br />
 +
**[[7dbk]] – hLDH B chain + NAD <br />
 +
**[[7epm]] – hLDH C chain + NAD <br />
**[[4i8x]], [[4i9h]], [[4i9n]], [[4i9u]] – rLDH A chain + pyridine derivative - rabbit<br />
**[[4i8x]], [[4i9h]], [[4i9n]], [[4i9u]] – rLDH A chain + pyridine derivative - rabbit<br />
 +
**[[6p6u]] – rLDH A chain + AMP<br />
 +
**[[7p4g]] – rLDH A chain + citrate<br />
**[[4aj1]], [[4aj2]], [[4aj4]], [[4aje]], [[4ajh]], [[4aji]], [[4ajj]], [[4ajk]], [[4ajl]], [[4ajn]], [[4ajo]], [[4al4]], [[5kkc]] – raL-LDH A chain + inhibitor – rat<br />
**[[4aj1]], [[4aj2]], [[4aj4]], [[4aje]], [[4ajh]], [[4aji]], [[4ajj]], [[4ajk]], [[4ajl]], [[4ajn]], [[4ajo]], [[4al4]], [[5kkc]] – raL-LDH A chain + inhibitor – rat<br />
**[[5es3]] – raL-LDH + oxamate<br />
**[[5es3]] – raL-LDH + oxamate<br />
Line 65: Line 73:
**[[1u4o]], [[1u4s]], [[1u5a]], [[1xiv]] – PfL-LDH + inhibitor<BR />
**[[1u4o]], [[1u4s]], [[1u5a]], [[1xiv]] – PfL-LDH + inhibitor<BR />
**[[2xxb]] – TtL-LDH (mutant) + AMP<br />
**[[2xxb]] – TtL-LDH (mutant) + AMP<br />
-
**[[3pqf]] – BsL-LDH (mutant) + NAD<br />
+
**[[3pqf]], [[6j9u]] – BsL-LDH (mutant) + NAD<br />
**[[6j9t]] - LcLDH + fructose-bisphosphate<br />
**[[6j9t]] - LcLDH + fructose-bisphosphate<br />
**[[6j9u]] – LcLDH (mutant) + pyruvate<br />
**[[6j9u]] – LcLDH (mutant) + pyruvate<br />
**[[4uun]] – TvL-LDH + NAD<br />
**[[4uun]] – TvL-LDH + NAD<br />
**[[6h9s]] – LDH + NAD – ''Petrotoga mobilis''<br />
**[[6h9s]] – LDH + NAD – ''Petrotoga mobilis''<br />
 +
**[[6vdj]] – ApLDH + NAD derivative<br />
 +
**[[7nay]] – LDH + NAD – ''Selenomonas ruminatium''<br />
 +
**[[8grv]] – DdLDH + NAD <br />
*''L-LDH ternary complex with inhibitor''
*''L-LDH ternary complex with inhibitor''
Line 76: Line 87:
**[[1i0z]] - hL-LDH H chain + oxamate + NAD<BR />
**[[1i0z]] - hL-LDH H chain + oxamate + NAD<BR />
**[[1i10]] - hL-LDH M chain + oxamate + NAD<BR />
**[[1i10]] - hL-LDH M chain + oxamate + NAD<BR />
-
**[[4qo7]], [[4qo8]], [[4r68]], [[4r69]], [[4rls]], [[4zvv]], [[5ixs]], [[5ixy]], [[5w8k]], [[5w8l]], [[6bad]], [[6bag]], [[6bax]], [[6baz]], [[6bb0]], [[6bb1]], [[6bb2]], [[6bb3]] - hL-LDH A chain + inhibitor + NAD<br />
+
**[[4qo7]], [[4qo8]], [[4r68]], [[4r69]], [[4rls]], [[4zvv]], [[5ixs]], [[5ixy]], [[5w8k]], [[5w8l]], [[6bad]], [[6bag]], [[6bax]], [[6baz]], [[6bb0]], [[6bb1]], [[6bb2]], [[6bb3]], [[6q0d]], [[6sbu]], [[7m2n]] - hL-LDH A chain + inhibitor + NAD<br />
**[[5zjd]] - hL-LDH A chain + malonate + NAD<br />
**[[5zjd]] - hL-LDH A chain + malonate + NAD<br />
**[[9ldb]], [[9ldt]], [[6cep]], [[5yta]] - pL-LDH + oxamate + NAD – pig<br />
**[[9ldb]], [[9ldt]], [[6cep]], [[5yta]] - pL-LDH + oxamate + NAD – pig<br />
Line 103: Line 114:
**[[6k13]] – BmLDH + NAD + oxamate <br />
**[[6k13]] – BmLDH + NAD + oxamate <br />
**[[6ct6]] – LDH + NAD + oxamate – ''Eimeria maxima''<br />
**[[6ct6]] – LDH + NAD + oxamate – ''Eimeria maxima''<br />
 +
**[[7qh2]] – LDH + FAD + Fe – ''Acetobacterium woodii'' – Cryo EM<br />
*''L-LDH ternary complex with reactants''
*''L-LDH ternary complex with reactants''
**[[5ldh]] - pLDH + citrate + NAD-analog<br />
**[[5ldh]] - pLDH + citrate + NAD-analog<br />
 +
**[[3ldh]] - sdLDH + pyruvate + NAD<BR />
**[[3h3j]] – SaL-LDH (mutant) + pyruvate + NAD<BR />
**[[3h3j]] – SaL-LDH (mutant) + pyruvate + NAD<BR />
**[[3d4p]] - SaL-LDH + pyruvate + NAD<BR />
**[[3d4p]] - SaL-LDH + pyruvate + NAD<BR />
-
**[[2fn7]] - CpLDH + lactate + NAD<BR />
+
**[[2fn7]], [[4nd3]] - CpLDH + lactate + NAD<BR />
**[[4nd2]] - CpLDH + pyruvate + NAD-analog<br />
**[[4nd2]] - CpLDH + pyruvate + NAD-analog<br />
**[[4nd4]] - CpLDH + pyruvate + NAD<BR />
**[[4nd4]] - CpLDH + pyruvate + NAD<BR />
-
**[[3ldh]] - sdLDH + pyruvate + NAD<BR />
 
**[[3pqd]] - BsLDH + fructose-bisphosphate + NAD
**[[3pqd]] - BsLDH + fructose-bisphosphate + NAD
*L-LDH quaternary complex
*L-LDH quaternary complex
-
**[[4jnk]] - hL-LDH A chain + inhibitor + lactate + NAD<br />
+
**[[4jnk]], [[6mv8]], [[6mva]] - hL-LDH A chain + inhibitor + lactate + NAD<br />
**[[4okn]] - hL-LDH A chain + katamycin+ oxalate + NAD<br />
**[[4okn]] - hL-LDH A chain + katamycin+ oxalate + NAD<br />
 +
**[[7dbj]] - hL-LDH B chain + inhibitor+ oxamate + NAD<br />
**[[3vph]] - TcL-LDH + oxamate + NAD + fructose diphosphate<br />
**[[3vph]] - TcL-LDH + oxamate + NAD + fructose diphosphate<br />
 +
**[[6trx]] - PvL-LDH + GMP + UMP + AMP + CMP + malaria biomarker<br />
 +
**[[8ab3]] - CaL-LDH + inhibitor+ oxamate + NAD<br />
*D-LDH
*D-LDH
Line 126: Line 141:
**[[1j49]] – LdD-LDH + sulfate + NAD – ''Lactobacillus delbrueckii''<BR />
**[[1j49]] – LdD-LDH + sulfate + NAD – ''Lactobacillus delbrueckii''<BR />
**[[1j4a]] - LdD-LDH + sulfate<BR />
**[[1j4a]] - LdD-LDH + sulfate<BR />
-
**[[1f0x]] – EcD-LDH + FAD – ''Escherichia coli''<BR />
+
**[[4prk]], [[4prl]] - D-LDH – Lactobacillus jensenii<br />
 +
**[[3wx0]], [[5z1z]] – EcD-LDH – ''Escherichia coli''<br />
 +
**[[1f0x]] – EcD-LDH + FAD <BR />
**[[2dld]] - D-LDH + oxamate + NAD – ''Lactobacillus helveticus''<br />
**[[2dld]] - D-LDH + oxamate + NAD – ''Lactobacillus helveticus''<br />
-
**[[3wwy]], [[6abi]] – FnD-LDH – ''Fusobacterium nucleatum''<br />
+
**[[6abi]] – FnD-LDH – ''Fusobacterium nucleatum''<br />
**[[5z21]] – FnD-LDH + NAD + oxamate<br />
**[[5z21]] – FnD-LDH + NAD + oxamate<br />
-
**[[3wwz]] – PaD-LDH – ''Peudomonas aeruginosa''<br />
+
**[[6abj]] – PaD-LDH – ''Peudomonas aeruginosa''<br />
**[[5z20]] – FnD-LDH + NAD + oxamate<br />
**[[5z20]] – FnD-LDH + NAD + oxamate<br />
**[[4xkj]] – D-LDH + NAD – ''Sporolactobacillus inulinus''<br />
**[[4xkj]] – D-LDH + NAD – ''Sporolactobacillus inulinus''<br />
**[[4cuj]] – SeD-LDH – ''Salmonella enterica''<br />
**[[4cuj]] – SeD-LDH – ''Salmonella enterica''<br />
**[[4cuk]] – SeD-LDH + NAD <br />
**[[4cuk]] – SeD-LDH + NAD <br />
 +
**[[7jp2]] – D-LDH – ''Treponema pallidum''<br />
*L-LDH II
*L-LDH II

Current revision

3D structures of lactate dehydrogenase

Updated on 15-June-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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