6-aminohexanoate-dimer hydrolase

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<StructureSection load='2zm9' size='350' side='right' caption='Structure of 6-aminohexanoate-dimer hydrolase complex with 6-aminohexanoate (PDB code [[2zm9]]).' scene='59/596399/Cv/1'>
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<StructureSection load='2zm9' size='400' side='right' caption='Structure of 6-aminohexanoate-dimer hydrolase complex with 6-aminohexanoate (PDB code [[2zm9]]).' scene='59/596399/Cv/1'>
== Function ==
== Function ==
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'''6-aminohexanoate-dimer hydrolase''' (AHDH) catalyzes the conversion of N-(6-aminohexanoyl)-6-aminohexanoate to 6-aminohexanoate monomers. AHDH is part of the xenobiotic degradation<ref>PMID:22187439</ref>
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'''6-aminohexanoate-dimer hydrolase''' (AHDH) catalyzes the conversion of N-(6-aminohexanoyl)-6-aminohexanoate to 6-aminohexanoate monomers. AHDH is part of the xenobiotic degradation<ref>PMID:22187439</ref>. It belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides<ref>PMID:7262074</ref>.
== Relevance ==
== Relevance ==
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== Structural highlights ==
== Structural highlights ==
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<scene name='59/596399/Cv/3'>6-aminohexanoate binding site</scene> (PDB code [[2zm9]]).
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<scene name='59/596399/Cv/5'>6-aminohexanoate binding site</scene> (PDB code [[2zm9]]).<ref>PMID:19521995</ref> Water molecules are shown as red spheres.
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</StructureSection>
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==3D structures of 6-aminohexanoate-dimer hydrolase==
==3D structures of 6-aminohexanoate-dimer hydrolase==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[6-aminohexanoate-dimer hydrolase 3D structures]]
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*6-aminohexanoate-dimer hydrolase
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</StructureSection>
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**[[1wyb]] – FlAHDH – ''Flavobacterium''<br />
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**[[1wyc]], [[2e8i]], [[2zm0]], [[3vwl]], [[3vwm]], [[3vwn]] – FlAHDH (mutant)<br />
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**[[3a2p]] – ArAHDH – ''Arthrobacter''<br />
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**[[4gb7]] – AHDH – ''Bacillus anthracis''<br />
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**[[2dcf]], [[2zm7]], [[2zma]], [[2zm9]], [[2zly]], [[2zm2]], [[3a65]], [[3a66]], [[3vwp]], [[3vwq]], [[3vwr]] – FlAHDH (mutant) + 6-aminohexanoate<br />
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**[[2zm8]] – FlAHDH (mutant) + 6-aminohexanoate-dimer<br />
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**[[3a2q]] – ArAHDH (mutant) + 6-aminohexanoate<br />
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}}
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== References ==
== References ==

Current revision

Structure of 6-aminohexanoate-dimer hydrolase complex with 6-aminohexanoate (PDB code 2zm9).

Drag the structure with the mouse to rotate

References

  1. ↑ Negoro S, Shibata N, Tanaka Y, Yasuhira K, Shibata H, Hashimoto H, Lee YH, Oshima S, Santa R, Oshima S, Mochiji K, Goto Y, Ikegami T, Nagai K, Kato D, Takeo M, Higuchi Y. Three-dimensional structure of nylon hydrolase and mechanism of nylon-6 hydrolysis. J Biol Chem. 2012 Feb 10;287(7):5079-90. doi: 10.1074/jbc.M111.321992. Epub 2011 , Dec 19. PMID:22187439 doi:http://dx.doi.org/10.1074/jbc.M111.321992
  2. ↑ Kinoshita S, Terada T, Taniguchi T, Takene Y, Masuda S, Matsunaga N, Okada H. Purification and characterization of 6-aminohexanoic-acid-oligomer hydrolase of Flavobacterium sp. Ki72. Eur J Biochem. 1981 Jun 1;116(3):547-51. PMID:7262074 doi:10.1111/j.1432-1033.1981.tb05371.x
  3. ↑ Ohki T, Shibata N, Higuchi Y, Kawashima Y, Takeo M, Kato D, Negoro S. Two alternative modes for optimizing nylon-6 byproduct hydrolytic activity from a carboxylesterase with a beta-lactamase fold: X-ray crystallographic analysis of directly evolved 6-aminohexanoate-dimer hydrolase. Protein Sci. 2009 Aug;18(8):1662-73. PMID:19521995 doi:10.1002/pro.185

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Alexander Berchansky, Michal Harel, Joel L. Sussman

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