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1qgt

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[[Image:1qgt.gif|left|200px]]
 
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==HUMAN HEPATITIS B VIRAL CAPSID (HBCAG)==
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The line below this paragraph, containing "STRUCTURE_1qgt", creates the "Structure Box" on the page.
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<StructureSection load='1qgt' size='340' side='right'caption='[[1qgt]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qgt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_B_virus Hepatitis B virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QGT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qgt OCA], [https://pdbe.org/1qgt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qgt RCSB], [https://www.ebi.ac.uk/pdbsum/1qgt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qgt ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_1qgt| PDB=1qgt | SCENE= }}
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== Function ==
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[https://www.uniprot.org/uniprot/Q67855_HBV Q67855_HBV]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hepatitis B is a small enveloped DNA virus that poses a major hazard to human health. The crystal structure of the T = 4 capsid has been solved at 3.3 A resolution, revealing a largely helical protein fold that is unusual for icosahedral viruses. The monomer fold is stabilized by a hydrophobic core that is highly conserved among human viral variants. Association of two amphipathic alpha-helical hairpins results in formation of a dimer with a four-helix bundle as the major central feature. The capsid is assembled from dimers via interactions involving a highly conserved region near the C terminus of the truncated protein used for crystallization. The major immunodominant region lies at the tips of the alpha-helical hairpins that form spikes on the capsid surface.
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'''HUMAN HEPATITIS B VIRAL CAPSID (HBCAG)'''
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The crystal structure of the human hepatitis B virus capsid.,Wynne SA, Crowther RA, Leslie AG Mol Cell. 1999 Jun;3(6):771-80. PMID:10394365<ref>PMID:10394365</ref>
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==Overview==
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Hepatitis B is a small enveloped DNA virus that poses a major hazard to human health. The crystal structure of the T = 4 capsid has been solved at 3.3 A resolution, revealing a largely helical protein fold that is unusual for icosahedral viruses. The monomer fold is stabilized by a hydrophobic core that is highly conserved among human viral variants. Association of two amphipathic alpha-helical hairpins results in formation of a dimer with a four-helix bundle as the major central feature. The capsid is assembled from dimers via interactions involving a highly conserved region near the C terminus of the truncated protein used for crystallization. The major immunodominant region lies at the tips of the alpha-helical hairpins that form spikes on the capsid surface.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1QGT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_b_virus Hepatitis b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QGT OCA].
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</div>
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<div class="pdbe-citations 1qgt" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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The crystal structure of the human hepatitis B virus capsid., Wynne SA, Crowther RA, Leslie AG, Mol Cell. 1999 Jun;3(6):771-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10394365 10394365]
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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[[Category: Hepatitis b virus]]
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== References ==
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[[Category: Single protein]]
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<references/>
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[[Category: Crowther, R A.]]
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__TOC__
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[[Category: Leslie, A G.W.]]
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</StructureSection>
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[[Category: Wynne, S A.]]
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[[Category: Hepatitis B virus]]
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[[Category: Icosahedral virus]]
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[[Category: Large Structures]]
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[[Category: Viral capsid protein]]
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[[Category: Crowther RA]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:15:09 2008''
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[[Category: Leslie AGW]]
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[[Category: Wynne SA]]

Current revision

HUMAN HEPATITIS B VIRAL CAPSID (HBCAG)

PDB ID 1qgt

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