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1qys

From Proteopedia

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[[Image:1qys.gif|left|200px]]
 
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==Crystal structure of Top7: A computationally designed protein with a novel fold==
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The line below this paragraph, containing "STRUCTURE_1qys", creates the "Structure Box" on the page.
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<StructureSection load='1qys' size='340' side='right'caption='[[1qys]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qys]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Computationally_Designed_Sequence Computationally Designed Sequence]. The October 2005 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Designer Proteins'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2005_10 10.2210/rcsb_pdb/mom_2005_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QYS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qys OCA], [https://pdbe.org/1qys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qys RCSB], [https://www.ebi.ac.uk/pdbsum/1qys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qys ProSAT]</span></td></tr>
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{{STRUCTURE_1qys| PDB=1qys | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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'''Crystal structure of Top7: A computationally designed protein with a novel fold'''
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== Publication Abstract from PubMed ==
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==Overview==
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A major challenge of computational protein design is the creation of novel proteins with arbitrarily chosen three-dimensional structures. Here, we used a general computational strategy that iterates between sequence design and structure prediction to design a 93-residue alpha/beta protein called Top7 with a novel sequence and topology. Top7 was found experimentally to be folded and extremely stable, and the x-ray crystal structure of Top7 is similar (root mean square deviation equals 1.2 angstroms) to the design model. The ability to design a new protein fold makes possible the exploration of the large regions of the protein universe not yet observed in nature.
A major challenge of computational protein design is the creation of novel proteins with arbitrarily chosen three-dimensional structures. Here, we used a general computational strategy that iterates between sequence design and structure prediction to design a 93-residue alpha/beta protein called Top7 with a novel sequence and topology. Top7 was found experimentally to be folded and extremely stable, and the x-ray crystal structure of Top7 is similar (root mean square deviation equals 1.2 angstroms) to the design model. The ability to design a new protein fold makes possible the exploration of the large regions of the protein universe not yet observed in nature.
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==About this Structure==
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Design of a novel globular protein fold with atomic-level accuracy.,Kuhlman B, Dantas G, Ireton GC, Varani G, Stoddard BL, Baker D Science. 2003 Nov 21;302(5649):1364-8. PMID:14631033<ref>PMID:14631033</ref>
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The following page contains interesting information on the relation of 1QYS with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QYS OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Design of a novel globular protein fold with atomic-level accuracy., Kuhlman B, Dantas G, Ireton GC, Varani G, Stoddard BL, Baker D, Science. 2003 Nov 21;302(5649):1364-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14631033 14631033]
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</div>
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<div class="pdbe-citations 1qys" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Computationally Designed Sequence]]
[[Category: Designer Proteins]]
[[Category: Designer Proteins]]
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[[Category: Baker, D.]]
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[[Category: Large Structures]]
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[[Category: Dantas, G.]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Ireton, G C.]]
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[[Category: Baker D]]
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[[Category: Kuhlman, B.]]
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[[Category: Dantas G]]
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[[Category: Stoddard, B L.]]
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[[Category: Ireton GC]]
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[[Category: Varani, G.]]
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[[Category: Kuhlman B]]
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[[Category: Alpha-beta]]
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[[Category: Stoddard BL]]
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[[Category: Computationally designed]]
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[[Category: Varani G]]
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[[Category: Novel fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:51:58 2008''
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Current revision

Crystal structure of Top7: A computationally designed protein with a novel fold

PDB ID 1qys

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