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MDM2 3D structures

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(New page: ==3D structures of MDM2== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *'''MDM2''' **2ruh - hMDM2 p53-bindi...)
Current revision (09:25, 27 June 2023) (edit) (undo)
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
-
*'''MDM2'''
+
*'''MDM2''' ); Domains – p53-binding 24-220; ring – 383-446; C4 zinc-finger 429-491
-
**[[2ruh]] - hMDM2 p53-binding domain residues 24-110 - human<br />
+
**[[8bgu]] - hMDM2 + RNA - human<br />
 +
**[[2ruh]] - hMDM2 p53-binding domain <br />
**[[1z1m]] – hMDM2 p53-binding domain - NMR<br />
**[[1z1m]] – hMDM2 p53-binding domain - NMR<br />
-
**[[2c6a]], [[2c6b]], [[2cr8]] – hMDM2 C4 Zinc-finger domain residues 300-339 - NMR<br />
+
**[[2c6a]], [[2c6b]] – hMDM2 C4 Zinc-finger domain - NMR<br />
-
**[[2hdp]] - hMDM2 C4 ring-finger domain residues 429-491 - NMR<br />
+
**[[2hdp]] - hMDM2 C4 ring-finger domain - NMR<br />
 +
**[[6sqp]] - cMDM2 C4 ring-finger domain – cat<br />
**[[4ipf]], [[4j74]] – fMDM2 p53-binding domain (mutant) - frog<br />
**[[4ipf]], [[4j74]] – fMDM2 p53-binding domain (mutant) - frog<br />
 +
**[[7ahy]] - fMDM2 RING domain <br />
 +
**[[7ah2]] - MDM2 RING domain – zebrafish<br />
-
*MDM2 complex with small molecule
+
*MDM2 p53-binding domain complex with small molecule
-
**[[1rv1]], [[1t4e]], [[3lbk]], [[4dij]], [[3vzv]], [[3w69]], [[3lkb]], [[4lwt]], [[4lwu]], [[4lwv]], [[4oq3]], [[5hmh]], [[5hmi]], [[5hmk]] – hMDM2 (mutant) p53-binding domain + inhibitor<br />
+
**[[1rv1]], [[1t4e]], [[3lbk]], [[4dij]], [[3vzv]], [[3w69]], [[3lkb]], [[4lwt]], [[4lwu]], [[4lwv]], [[4oq3]], [[5hmh]], [[5hmi]], [[5hmk]] – hMDM2 (mutant) + inhibitor<br />
-
**[[3jzk]], [[3lbl]], [[3tu1]], [[4ere]], [[4erf]], [[3tj2]], [[4hbm]], [[4jv7]], [[4jv9]], [[4jve]], [[4jvr]], [[4jwr]], [[4mdn]], [[4mdq]], [[4oas]], [[4oba]], [[4occ]], [[4ode]], [[4odf]], [[4ogn]], [[4ogt]], [[4ogv]], [[4qo4]], [[4hg7]], [[4wt2]], [[4qoc]], [[4wt2]], [[4zfi]], [[4zgk]], [[4zyf]], [[4zyi]], [[5j7f]], [[5j7g]], [[5lav]], [[5law]], [[5lay]], [[5laz]], [[5ln2]], [[5trf]], [[6q96]], [[6q9h]], [[6q9l]], [[6q9o]], [[6i3s]], [[6ggn]], [[5oc8]], [[5oai]] - hMDM2 p53-binding domain + inhibitor<br />
+
**[[3jzk]], [[3lbl]], [[3tu1]], [[4ere]], [[4erf]], [[3tj2]], [[4hbm]], [[4jv7]], [[4jv9]], [[4jve]], [[4jvr]], [[4jwr]], [[4mdn]], [[4mdq]], [[4oas]], [[4oba]], [[4occ]], [[4ode]], [[4odf]], [[4ogn]], [[4ogt]], [[4ogv]], [[4qo4]], [[4hg7]], [[4wt2]], [[4qoc]], [[4wt2]], [[4zfi]], [[4zgk]], [[4zyf]], [[4zyi]], [[5j7f]], [[5j7g]], [[5lav]], [[5law]], [[5lay]], [[5laz]], [[5ln2]], [[5trf]], [[6q96]], [[6q9h]], [[6q9l]], [[6q9o]], [[6i3s]], [[6ggn]], [[5oc8]], [[5oai]], [[6i29]], [[7bir]], [[7bit]], [[7biv]], [[7bj0]], [[7bj6]], [[7bmg]], [[7na1]], [[7na2]], [[7na3]], [[7na4]], [[7qdq]], [[8aeu]] - hMDM2 + inhibitor<br />
-
**[[5z02]], [[5zxf]] - hMDM2  p53-binding domain +  nutlin<br />
+
**[[5z02]], [[5zxf]] - hMDM2 +  nutlin<br />
-
**[[2lzg]] - hMDM2 p53-binding domain + inhibitor – NMR<br />
+
**[[2lzg]] - hMDM2 + inhibitor – NMR<br />
-
**[[3vbg]] - hMDM2 p53-binding domain + indolyl hydantoin<br />
+
**[[3vbg]] - hMDM2 + indolyl hydantoin<br />
-
**[[5c5a]] - hMDM2 (mutant) p53-binding domain +  inhibitor – NMR<br />
+
**[[5c5a]] - hMDM2 (mutant) +  inhibitor – NMR<br />
-
**[[1ttv]] - fMDM2 (mutant) p53-binding domain + inhibitor – NMR<br />
+
**[[1ttv]] - fMDM2 (mutant) + inhibitor – NMR<br />
-
**[[4j3e]], [[4j7d]], [[4j7e]], [[4jrg]], [[4jsc]], [[4zyc]], [[4lwt]], [[4lwu]], [[4lwv]] - fMDM2 p53-binding domain (mutant) + inhibitor<br />
+
**[[4j3e]], [[4j7d]], [[4j7e]], [[4jrg]], [[4jsc]], [[4zyc]], [[4lwt]], [[4lwu]], [[4lwv]] - fMDM2 (mutant) + inhibitor<br />
*MDM2 complex with peptide
*MDM2 complex with peptide
-
**[[1ycq]], [[1ycr]] – fMDM2 + p53 peptide <br />
 
**[[1t4f]], [[4hfz]] - hMDM2 (mutant) p53-binding domain + p53 peptide<br />
**[[1t4f]], [[4hfz]] - hMDM2 (mutant) p53-binding domain + p53 peptide<br />
-
**[[3v3b]] - hMDM2 p53-binding domain + p53 peptide<br />
+
**[[3v3b]], [[7ad0]], [[7nus]] - hMDM2 p53-binding domain + p53 peptide<br />
**[[2mps]] - hMDM2 p53-binding domain + p73 peptide<br />
**[[2mps]] - hMDM2 p53-binding domain + p73 peptide<br />
**[[3jzr]] - hMDM2 p53-binding domain + pDI6W peptide<br />
**[[3jzr]] - hMDM2 p53-binding domain + pDI6W peptide<br />
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**[[3jzs]] - hMDM2 p53-binding domain + pDIQ peptide<br />
**[[3jzs]] - hMDM2 p53-binding domain + pDIQ peptide<br />
**[[3tpx]] - hMDM2 p53-binding domain + D-peptide inhibitor<br />
**[[3tpx]] - hMDM2 p53-binding domain + D-peptide inhibitor<br />
-
**[[2axi]], [[2gv2]], [[3eqs]], [[3g03]], [[3iux]], [[3lnj]], [[3lnz]], [[3iwy]], [[5umm]] - hMDM2 p53-binding domain + peptide<br />
+
**[[2axi]], [[2gv2]], [[3eqs]], [[3g03]], [[3iux]], [[3lnj]], [[3lnz]], [[3iwy]], [[5umm]], [[6hfa]], [[7kjm]], [[8f0z]], [[8f10]], [[8f12]], [[8f13]] - hMDM2 p53-binding domain + peptide inhibitor<br />
**[[5vk0]], [[6kzu]], [[6aaw]] - hMDM2  p53-binding domain + stapled peptide<br />
**[[5vk0]], [[6kzu]], [[6aaw]] - hMDM2  p53-binding domain + stapled peptide<br />
-
**[[4ud7]], [[4ue1]], [[4umn]], [[5afg]], [[5xxk]], [[6h22]] - hMDM2  p53-binding domain (mutant) + stapled peptide<br />
+
**[[4ud7]], [[4ue1]], [[4umn]], [[5afg]], [[5xxk]], [[6h22]], [[6t2d]], [[6t2e]], [[6t2f]], [[6y4q]] - hMDM2  p53-binding domain (mutant) + stapled peptide<br />
**[[2m86]] - hMDM2 p53-binding domain + cyclotide - NMR<br />
**[[2m86]] - hMDM2 p53-binding domain + cyclotide - NMR<br />
**[[2vje]], [[2vjf]] - hMDM2 ring domain + MDM4 peptide<br />
**[[2vje]], [[2vjf]] - hMDM2 ring domain + MDM4 peptide<br />
 +
**[[1ycq]], [[1ycr]] – fMDM2 p53-binding domain + p53 peptide <br />
*MDM2 complex with protein
*MDM2 complex with protein
-
**[[5mnj]] - hMDM2 residues 428-491 + MDM4 + polyubiquitin + ubiquitin-conjugating enzyme E2<br />
+
**[[5mnj]] - hMDM2 C4 zinc-finger domain + MDM4 + polyubiquitin + ubiquitin-conjugating enzyme E2<br />
**[[5wts]] - hMDM2  p53-binding domain + GFP-linked peptide<br />
**[[5wts]] - hMDM2  p53-binding domain + GFP-linked peptide<br />
**[[5swk]] - hMDM2  p53-binding domain + cysteine protease inhibitor<br />
**[[5swk]] - hMDM2  p53-binding domain + cysteine protease inhibitor<br />
**[[6im9]] - hMDM2  p53-binding domain + copper reflux oxidase<br />
**[[6im9]] - hMDM2  p53-binding domain + copper reflux oxidase<br />
 +
**[[7aye]] - hMDM2  p53-binding domain + DsbD<br />
 +
**[[6sqo]] - hMDM2  ring domain + ubiquitin-conjugating enzyme E2 + S27A<br />
 +
**[[6sqr]], [[6sqs]] - cMDM2  ring domain + ubiquitin-conjugating enzyme E2 + S27A<br />
 +
**[[7ahz]], [[7ai0]], [[7ai1]] - fMDM2 RING domain (mutant) + polyubiquitin + ubiquitin-conjugating enzyme E2<br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D structures of MDM2

Updated on 27-June-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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