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7yab
From Proteopedia
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(New page: '''Unreleased structure''' The entry 7yab is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of zinc finger domain 1 of human ZFAND1== | |
| - | + | <StructureSection load='7yab' size='340' side='right'caption='[[7yab]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7yab]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YAB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yab OCA], [https://pdbe.org/7yab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yab RCSB], [https://www.ebi.ac.uk/pdbsum/7yab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yab ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ZFAN1_HUMAN ZFAN1_HUMAN] Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress (PubMed:29804830). Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome (PubMed:29804830). This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy (PubMed:29804830).<ref>PMID:29804830</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chang CF]] | ||
| + | [[Category: Fang PJ]] | ||
| + | [[Category: Hsu STD]] | ||
| + | [[Category: Ko KT]] | ||
| + | [[Category: Lai CH]] | ||
Current revision
Solution structure of zinc finger domain 1 of human ZFAND1
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Categories: Homo sapiens | Large Structures | Chang CF | Fang PJ | Hsu STD | Ko KT | Lai CH
