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5dgm

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Current revision (21:41, 28 June 2023) (edit) (undo)
 
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<StructureSection load='5dgm' size='340' side='right'caption='[[5dgm]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
<StructureSection load='5dgm' size='340' side='right'caption='[[5dgm]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5dgm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DGM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5DGM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5dgm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DGM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=59Z:{2-[(PHOSPHONOMETHYL)CARBAMOYL]-1H-BENZO[G]INDOL-1-YL}ACETIC+ACID'>59Z</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.86&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=59Z:{2-[(PHOSPHONOMETHYL)CARBAMOYL]-1H-BENZO[G]INDOL-1-YL}ACETIC+ACID'>59Z</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5dgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dgm OCA], [http://pdbe.org/5dgm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dgm RCSB], [http://www.ebi.ac.uk/pdbsum/5dgm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dgm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dgm OCA], [https://pdbe.org/5dgm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dgm RCSB], [https://www.ebi.ac.uk/pdbsum/5dgm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dgm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
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[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bourgier, E]]
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[[Category: Bourgier E]]
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[[Category: Lehmann, S]]
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[[Category: Lehmann S]]
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[[Category: Rondeau, J M]]
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[[Category: Rondeau JM]]
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[[Category: Cholesterol biosynthesis]]
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[[Category: Isoprene biosynthesis]]
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[[Category: Transferase]]
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Current revision

Crystal structure of human FPPS in complex with monophosphonate compound 7

PDB ID 5dgm

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