1ldp

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[[Image:1ldp.jpg|left|200px]]
[[Image:1ldp.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1ldp |SIZE=350|CAPTION= <scene name='initialview01'>1ldp</scene>, resolution 3.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1ldp", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=CNP:This+Nine+Amino+Acid+Model+Best+Fits+The+Electron+Densit+...'>CNP</scene> and <scene name='pdbsite=CNQ:This+Nine+Residue+Model+Of+Antigenic+Peptide+Ql9+Also+Fi+...'>CNQ</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= H-2LD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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-->
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|DOMAIN=
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{{STRUCTURE_1ldp| PDB=1ldp | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ldp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ldp OCA], [http://www.ebi.ac.uk/pdbsum/1ldp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ldp RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES'''
'''CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES'''
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[[Category: Speir, J A.]]
[[Category: Speir, J A.]]
[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
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[[Category: antigen presentation]]
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[[Category: Antigen presentation]]
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[[Category: antigen receptor]]
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[[Category: Antigen receptor]]
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[[Category: cell surface receptor]]
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[[Category: Cell surface receptor]]
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[[Category: cellular immunity]]
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[[Category: Cellular immunity]]
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[[Category: complex (mhc i/peptide)]]
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[[Category: Immunology]]
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[[Category: immunology]]
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[[Category: Major histocompatibility complex]]
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[[Category: major histocompatibility complex]]
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[[Category: Peptide antigen]]
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[[Category: peptide antigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:49:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:01:31 2008''
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Revision as of 20:49, 2 May 2008

Image:1ldp.jpg

Template:STRUCTURE 1ldp

CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES


Overview

MHC class I H-2Ld complexed with peptide QL9 (or p2Ca) is a high-affinity alloantigen for the 2C TCR. We used the crystal structure of H-2Ld with a mixture of bound peptides at 3.1 A to construct a model of the allogeneic 2C-Ld/QL9 complex for comparison with the syngeneic 2C-Kb/dEV8 structure. A prominent ridge on the floor of the Ld peptide-binding groove, not present in Kb, creates a C-terminal bulge in Ld peptides that greatly increases interactions with the 2C beta-chain. Furthermore, weak electrostatic complementarity between Asp77 on the alpha1 helix of Kb and 2C is enhanced in the allogeneic complex by closer proximity of QL9 peptide residue AspP8 to the 2C HV4 loop.

About this Structure

1LDP is a Protein complex structure of sequences from Drosophila melanogaster and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes., Speir JA, Garcia KC, Brunmark A, Degano M, Peterson PA, Teyton L, Wilson IA, Immunity. 1998 May;8(5):553-62. PMID:9620676 Page seeded by OCA on Fri May 2 23:49:25 2008

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OCA

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