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5dt2

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Current revision (21:58, 28 June 2023) (edit) (undo)
 
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<StructureSection load='5dt2' size='340' side='right'caption='[[5dt2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='5dt2' size='340' side='right'caption='[[5dt2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5dt2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DT2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5DT2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5dt2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DT2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5EV:N~4~-METHYL-N~2~-[2-METHYL-1-(2-PHENOXYPHENYL)-1H-INDOL-6-YL]PYRIMIDINE-2,4-DIAMINE'>5EV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DOT1L, KIAA1814, KMT4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5EV:N~4~-METHYL-N~2~-[2-METHYL-1-(2-PHENOXYPHENYL)-1H-INDOL-6-YL]PYRIMIDINE-2,4-DIAMINE'>5EV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dt2 OCA], [https://pdbe.org/5dt2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dt2 RCSB], [https://www.ebi.ac.uk/pdbsum/5dt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dt2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5dt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dt2 OCA], [http://pdbe.org/5dt2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dt2 RCSB], [http://www.ebi.ac.uk/pdbsum/5dt2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dt2 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN]] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
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[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Histone-lysine N-methyltransferase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Be, C]]
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[[Category: Be C]]
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[[Category: Gaul, C]]
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[[Category: Gaul C]]
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[[Category: Moebitz, H]]
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[[Category: Moebitz H]]
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[[Category: Scheufler, C]]
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[[Category: Scheufler C]]
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[[Category: Complex]]
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[[Category: Inhibitor]]
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[[Category: Methyltransferase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Dot1L in complex with inhibitor CPD11 [N4-methyl-N2-(2-methyl-1-(2-phenoxyphenyl)-1H-indol-6-yl)pyrimidine-2,4-diamine]

PDB ID 5dt2

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