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8j18
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the 3-OH-C12-bound GPR84 receptor-Gi complex== | |
| - | + | <StructureSection load='8j18' size='340' side='right'caption='[[8j18]], [[Resolution|resolution]] 2.89Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8j18]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J18 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.89Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HXD:(3R)-3-HYDROXYDODECANOIC+ACID'>HXD</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j18 OCA], [https://pdbe.org/8j18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j18 RCSB], [https://www.ebi.ac.uk/pdbsum/8j18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j18 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Liu | + | == Function == |
| + | [https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Liu H]] | ||
| + | [[Category: Xu HE]] | ||
| + | [[Category: Yin W]] | ||
Current revision
Cryo-EM structure of the 3-OH-C12-bound GPR84 receptor-Gi complex
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