This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5e56
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5e56 is ON HOLD Authors: Fedorov, A.A., Fedorov, E.V., SAMANTA, D, BONNANO, J.B., ALMO, S.C. Description: Crystal structure of mouse CTLA-4 [[Categ...) |
|||
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of mouse CTLA-4== | |
| + | <StructureSection load='5e56' size='340' side='right'caption='[[5e56]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5e56]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E56 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.504Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e56 OCA], [https://pdbe.org/5e56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e56 RCSB], [https://www.ebi.ac.uk/pdbsum/5e56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e56 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CTLA4_MOUSE CTLA4_MOUSE] Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[CTLA-4|CTLA-4]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Almo | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: | + | [[Category: Almo SC]] |
| - | [[Category: Fedorov | + | [[Category: Bonanno JB]] |
| + | [[Category: Fedorov AA]] | ||
| + | [[Category: Fedorov EV]] | ||
| + | [[Category: SAMANTA D]] | ||
Current revision
Crystal structure of mouse CTLA-4
| |||||||||||
