This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5e7d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:15, 5 July 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand==
==Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand==
-
<StructureSection load='5e7d' size='340' side='right' caption='[[5e7d]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
+
<StructureSection load='5e7d' size='340' side='right'caption='[[5e7d]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5e7d]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E7D FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5e7d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E7D FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5KL:(2E)-3-(DIMETHYLAMINO)-1-(2-HYDROXYPHENYL)PROP-2-EN-1-ONE'>5KL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e7d OCA], [http://pdbe.org/5e7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e7d RCSB], [http://www.ebi.ac.uk/pdbsum/5e7d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e7d ProSAT]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5KL:(2E)-3-(DIMETHYLAMINO)-1-(2-HYDROXYPHENYL)PROP-2-EN-1-ONE'>5KL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e7d OCA], [https://pdbe.org/5e7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e7d RCSB], [https://www.ebi.ac.uk/pdbsum/5e7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e7d ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[http://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
+
[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>
+
[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Arrowsmith, C H]]
+
[[Category: Homo sapiens]]
-
[[Category: Bountra, C]]
+
[[Category: Large Structures]]
-
[[Category: Delft, F von]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Edwards, A]]
+
[[Category: Bountra C]]
-
[[Category: Filippakopoulos, P]]
+
[[Category: Edwards A]]
-
[[Category: Knapp, S]]
+
[[Category: Filippakopoulos P]]
-
[[Category: Owen, D]]
+
[[Category: Knapp S]]
-
[[Category: Picaud, S]]
+
[[Category: Owen D]]
-
[[Category: Structural genomic]]
+
[[Category: Picaud S]]
-
[[Category: Bromodomain]]
+
[[Category: Von Delft F]]
-
[[Category: Chemical probe]]
+
-
[[Category: Inhibitor]]
+
-
[[Category: Ligand]]
+
-
[[Category: Sgc]]
+
-
[[Category: Transcription]]
+

Current revision

Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand

PDB ID 5e7d

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5e7d"
Personal tools