This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5eh0
From Proteopedia
(Difference between revisions)
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
==Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach== | ==Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach== | ||
| - | <StructureSection load='5eh0' size='340' side='right' caption='[[5eh0]], [[Resolution|resolution]] 2.18Å' scene=''> | + | <StructureSection load='5eh0' size='340' side='right'caption='[[5eh0]], [[Resolution|resolution]] 2.18Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5eh0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EH0 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5eh0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EH0 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5NW:N2-(2-METHOXY-4-(1-METHYL-1H-PYRAZOL-4-YL)PHENYL)-N8-NEOPENTYLPYRIDO[3,4-D]PYRIMIDINE-2,8-DIAMINE'>5NW</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5NW:N2-(2-METHOXY-4-(1-METHYL-1H-PYRAZOL-4-YL)PHENYL)-N8-NEOPENTYLPYRIDO[3,4-D]PYRIMIDINE-2,8-DIAMINE'>5NW</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eh0 OCA], [https://pdbe.org/5eh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eh0 RCSB], [https://www.ebi.ac.uk/pdbsum/5eh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eh0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 16: | Line 19: | ||
</div> | </div> | ||
<div class="pdbe-citations 5eh0" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5eh0" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Baker R]] |
| - | [[Category: | + | [[Category: Blagg J]] |
| - | [[Category: Burke | + | [[Category: Box G]] |
| - | [[Category: Cronin | + | [[Category: Burke R]] |
| - | [[Category: | + | [[Category: Cronin N]] |
| - | [[Category: | + | [[Category: De Haven Brandon A]] |
| - | [[Category: | + | [[Category: Eccles SA]] |
| - | [[Category: Hayes | + | [[Category: Faisal A]] |
| - | [[Category: Henley | + | [[Category: Hayes A]] |
| - | [[Category: Hoelder | + | [[Category: Henley AT]] |
| - | [[Category: Innocenti | + | [[Category: Hoelder S]] |
| - | [[Category: Linardopoulos | + | [[Category: Innocenti P]] |
| - | [[Category: Mak | + | [[Category: Linardopoulos S]] |
| - | [[Category: | + | [[Category: Mak G]] |
| - | [[Category: | + | [[Category: Naud N]] |
| - | [[Category: Raymaud | + | [[Category: O'Fee L]] |
| - | [[Category: Roberts | + | [[Category: Raymaud FI]] |
| - | [[Category: Saville | + | [[Category: Roberts J]] |
| - | [[Category: Schmitt | + | [[Category: Saville J]] |
| - | [[Category: Solanki | + | [[Category: Schmitt J]] |
| - | [[Category: Valenti | + | [[Category: Solanki S]] |
| - | [[Category: Westwood | + | [[Category: Valenti M]] |
| - | [[Category: Woodward | + | [[Category: Westwood IM]] |
| - | [[Category: | + | [[Category: Woodward HL]] |
| + | [[Category: Van Montfort RLM]] | ||
Current revision
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach
| |||||||||||
Categories: Homo sapiens | Large Structures | Baker R | Blagg J | Box G | Burke R | Cronin N | De Haven Brandon A | Eccles SA | Faisal A | Hayes A | Henley AT | Hoelder S | Innocenti P | Linardopoulos S | Mak G | Naud N | O'Fee L | Raymaud FI | Roberts J | Saville J | Schmitt J | Solanki S | Valenti M | Westwood IM | Woodward HL | Van Montfort RLM
