5ehf
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5ehf is ON HOLD Authors: Polyakov, K.M., Glazunova, O.A., Fedorova, T.V., Dorovatovskii, P.V., Koroleva, O.V. Description: Laccase from Antrodiella...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Laccase from Antrodiella faginea== | |
| + | <StructureSection load='5ehf' size='340' side='right'caption='[[5ehf]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5ehf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Antrodiella_faginea Antrodiella faginea]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5dao 5dao]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EHF FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ehf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ehf OCA], [https://pdbe.org/5ehf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ehf RCSB], [https://www.ebi.ac.uk/pdbsum/5ehf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ehf ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A0M3U1T9_9APHY A0A0M3U1T9_9APHY] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Laccases are multicopper oxidases that catalyze oxidation of a wide range of organic and inorganic substrates accompanied by the reduction of dioxygen to water. The physicochemical and catalytic properties of two new fungal laccases from basidiomycetes Antrodiella faginea (AfL) and Steccherinum murashkinskyi (SmL) with middle redox potential of the T1 copper site were studied. The X-ray structures of AfL and SmL were solved at 1.75A and 0.95A, respectively. The oxidized state of copper ions in the active site was observed in AfL structure, while the mixture of oxidized and reduced states was observed in SmL structure. These oxidized and reduced states relate to the position of copper ions, their coordination, and nature and position of oxygen ligands. Comparative analysis of the T1 site environment of laccases with known structure allowed us to highlight the six types of the secondary coordination sphere of the T1 copper. The solvent accessible surface area of the conservative region of the secondary coordination sphere of the T1 copper correlates with its the redox potential. It was shown that the laccase classification by the structure of the T1 copper secondary coordination sphere is in agreement to ecophysiological behavior of laccase producing fungi. | ||
| - | + | Structure-function study of two new middle-redox potential laccases from basidiomycetes Antrodiella faginea and Steccherinum murashkinskyi.,Glazunova OA, Polyakov KM, Moiseenko KV, Kurzeev SA, Fedorova TV Int J Biol Macromol. 2018 Jun 15;118(Pt A):406-418. doi:, 10.1016/j.ijbiomac.2018.06.038. PMID:29890251<ref>PMID:29890251</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5ehf" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | |
| - | [[Category: | + | ==See Also== |
| - | [[Category: | + | *[[Laccase 3D structures|Laccase 3D structures]] |
| - | [[Category: Polyakov | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Antrodiella faginea]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dorovatovskii PV]] | ||
| + | [[Category: Fedorova TV]] | ||
| + | [[Category: Glazunova OA]] | ||
| + | [[Category: Koroleva OV]] | ||
| + | [[Category: Polyakov KM]] | ||
Current revision
Laccase from Antrodiella faginea
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