5ei4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:29, 5 July 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==First domain of human bromodomain BRD4 in complex with inhibitor 8-(5-Amino-1H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-(4-chlorobenzyl)-7-ethyl-3,7-dihydropurine-2,6-dione==
==First domain of human bromodomain BRD4 in complex with inhibitor 8-(5-Amino-1H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-(4-chlorobenzyl)-7-ethyl-3,7-dihydropurine-2,6-dione==
-
<StructureSection load='5ei4' size='340' side='right' caption='[[5ei4]], [[Resolution|resolution]] 1.05&Aring;' scene=''>
+
<StructureSection load='5ei4' size='340' side='right'caption='[[5ei4]], [[Resolution|resolution]] 1.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5ei4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EI4 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5ei4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EI4 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5NV:8-[(3-AZANYL-1~{H}-1,2,4-TRIAZOL-5-YL)SULFANYLMETHYL]-3-[(4-CHLOROPHENYL)METHYL]-7-ETHYL-PURINE-2,6-DIONE'>5NV</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.05&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ei4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ei4 OCA], [http://pdbe.org/5ei4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ei4 RCSB], [http://www.ebi.ac.uk/pdbsum/5ei4 PDBsum]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5NV:8-[(3-AZANYL-1~{H}-1,2,4-TRIAZOL-5-YL)SULFANYLMETHYL]-3-[(4-CHLOROPHENYL)METHYL]-7-ETHYL-PURINE-2,6-DIONE'>5NV</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ei4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ei4 OCA], [https://pdbe.org/5ei4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ei4 RCSB], [https://www.ebi.ac.uk/pdbsum/5ei4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ei4 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 22: Line 23:
==See Also==
==See Also==
-
*[[Bromodomain-containing protein|Bromodomain-containing protein]]
+
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Betzi, S]]
+
[[Category: Homo sapiens]]
-
[[Category: Morelli, X]]
+
[[Category: Large Structures]]
-
[[Category: Raux, B]]
+
[[Category: Betzi S]]
-
[[Category: Rebuffet, E]]
+
[[Category: Morelli X]]
-
[[Category: Brd4]]
+
[[Category: Raux B]]
-
[[Category: Brd4_bd1]]
+
[[Category: Rebuffet E]]
-
[[Category: Brd4_bd1 29-o]]
+
-
[[Category: Bromodomain]]
+
-
[[Category: Epigenetic reader]]
+
-
[[Category: Histone]]
+
-
[[Category: Inhibitor]]
+
-
[[Category: Transcription]]
+

Current revision

First domain of human bromodomain BRD4 in complex with inhibitor 8-(5-Amino-1H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-(4-chlorobenzyl)-7-ethyl-3,7-dihydropurine-2,6-dione

PDB ID 5ei4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5ei4"
Personal tools