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5eix

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==QUINOLONE-STABILIZED CLEAVAGE COMPLEX OF TOPOISOMERASE IV FROM KLEBSIELLA PNEUMONIAE==
==QUINOLONE-STABILIZED CLEAVAGE COMPLEX OF TOPOISOMERASE IV FROM KLEBSIELLA PNEUMONIAE==
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<StructureSection load='5eix' size='340' side='right' caption='[[5eix]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
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<StructureSection load='5eix' size='340' side='right'caption='[[5eix]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5eix]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EIX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EIX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5eix]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EIX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFX:(3S)-9-FLUORO-3-METHYL-10-(4-METHYLPIPERAZIN-1-YL)-7-OXO-2,3-DIHYDRO-7H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC+ACID'>LFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rae|3rae]], [[3ltn|3ltn]], [[3rad|3rad]], [[3raf|3raf]], [[4i3h|4i3h]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LFX:(3S)-9-FLUORO-3-METHYL-10-(4-METHYLPIPERAZIN-1-YL)-7-OXO-2,3-DIHYDRO-7H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC+ACID'>LFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eix OCA], [http://pdbe.org/5eix PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eix RCSB], [http://www.ebi.ac.uk/pdbsum/5eix PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eix OCA], [https://pdbe.org/5eix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eix RCSB], [https://www.ebi.ac.uk/pdbsum/5eix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eix ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/R4YHS8_KLEPR R4YHS8_KLEPR] [https://www.uniprot.org/uniprot/R4YE07_KLEPR R4YE07_KLEPR] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.[HAMAP-Rule:MF_00936]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5eix" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5eix" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Branstrom, A]]
 
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[[Category: Fisher, L M]]
 
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[[Category: Laponogov, I]]
 
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[[Category: Pan, X S]]
 
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[[Category: Sanderson, M R]]
 
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[[Category: Selvarajah, J]]
 
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[[Category: Veselkov, D A]]
 
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[[Category: Cleavage complex]]
 
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[[Category: Dna binding]]
 
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[[Category: Isomerase]]
 
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[[Category: Isomerase-dna complex]]
 
[[Category: Klebsiella pneumoniae]]
[[Category: Klebsiella pneumoniae]]
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[[Category: Levofloxacin]]
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[[Category: Large Structures]]
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[[Category: Quinolone]]
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[[Category: Synthetic construct]]
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[[Category: Topoisomerase iv]]
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[[Category: Branstrom A]]
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[[Category: Fisher LM]]
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[[Category: Laponogov I]]
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[[Category: Pan X-S]]
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[[Category: Sanderson MR]]
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[[Category: Selvarajah J]]
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[[Category: Veselkov DA]]

Current revision

QUINOLONE-STABILIZED CLEAVAGE COMPLEX OF TOPOISOMERASE IV FROM KLEBSIELLA PNEUMONIAE

PDB ID 5eix

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