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5ek9

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Current revision (06:31, 5 July 2023) (edit) (undo)
 
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==Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline inhibitor==
==Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline inhibitor==
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<StructureSection load='5ek9' size='340' side='right' caption='[[5ek9]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
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<StructureSection load='5ek9' size='340' side='right'caption='[[5ek9]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ek9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EK9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ek9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EK9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5P4:PROPAN-2-YL+~{N}-[(2~{S},4~{R})-1-ETHANOYL-6-(FURAN-2-YL)-2-METHYL-3,4-DIHYDRO-2~{H}-QUINOLIN-4-YL]CARBAMATE'>5P4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD2, KIAA9001, RING3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5P4:PROPAN-2-YL+~{N}-[(2~{S},4~{R})-1-ETHANOYL-6-(FURAN-2-YL)-2-METHYL-3,4-DIHYDRO-2~{H}-QUINOLIN-4-YL]CARBAMATE'>5P4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ek9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ek9 OCA], [http://pdbe.org/5ek9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ek9 RCSB], [http://www.ebi.ac.uk/pdbsum/5ek9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ek9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ek9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ek9 OCA], [https://pdbe.org/5ek9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ek9 RCSB], [https://www.ebi.ac.uk/pdbsum/5ek9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ek9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
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[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5ek9" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ek9" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bharatham, N]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bharatham N]]
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[[Category: Boyd, V A]]
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[[Category: Bountra C]]
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[[Category: Chai, S]]
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[[Category: Boyd VA]]
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[[Category: Chen, T]]
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[[Category: Chai S]]
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[[Category: Delft, F von]]
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[[Category: Chen T]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: Fedorov, O]]
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[[Category: Fedorov O]]
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[[Category: Guy, R K]]
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[[Category: Guy RK]]
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[[Category: Heroven, C]]
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[[Category: Heroven C]]
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[[Category: Knapp, S]]
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[[Category: Knapp S]]
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[[Category: Lee, R E]]
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[[Category: Lee RE]]
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[[Category: Picaud, S]]
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[[Category: Picaud S]]
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[[Category: Structural genomic]]
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[[Category: Shadrick WR]]
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[[Category: Shadrick, W R]]
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[[Category: Shelat AA]]
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[[Category: Shelat, A A]]
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[[Category: Siejka P]]
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[[Category: Siejka, P]]
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[[Category: Slavish PJ]]
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[[Category: Slavish, P J]]
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[[Category: Tallant C]]
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[[Category: Tallant, C]]
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[[Category: Young BM]]
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[[Category: Young, B M]]
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[[Category: Von Delft F]]
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[[Category: Acetylation]]
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[[Category: Chromatin and transcription regulator]]
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[[Category: Sgc]]
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[[Category: Transcription]]
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Current revision

Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline inhibitor

PDB ID 5ek9

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