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5elw

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==A. thaliana IGPD2 in complex with the triazole-phosphonate inhibitor, (R)-C348, to 1.36A resolution==
==A. thaliana IGPD2 in complex with the triazole-phosphonate inhibitor, (R)-C348, to 1.36A resolution==
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<StructureSection load='5elw' size='340' side='right' caption='[[5elw]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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<StructureSection load='5elw' size='340' side='right'caption='[[5elw]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5elw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ELW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ELW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5elw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ELW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ELW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5LD:[(2R)-2-HYDROXY-3-(1H-1,2,4-TRIAZOL-1-YL)PROPYL]PHOSPHONIC+ACID'>5LD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Imidazoleglycerol-phosphate_dehydratase Imidazoleglycerol-phosphate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.19 4.2.1.19] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5LD:[(2R)-2-HYDROXY-3-(1H-1,2,4-TRIAZOL-1-YL)PROPYL]PHOSPHONIC+ACID'>5LD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5elw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5elw OCA], [http://pdbe.org/5elw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5elw RCSB], [http://www.ebi.ac.uk/pdbsum/5elw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5elw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5elw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5elw OCA], [https://pdbe.org/5elw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5elw RCSB], [https://www.ebi.ac.uk/pdbsum/5elw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5elw ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HIS5B_ARATH HIS5B_ARATH]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Imidazoleglycerol-phosphate dehydratase]]
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[[Category: Arabidopsis thaliana]]
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[[Category: Baker, P J]]
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[[Category: Large Structures]]
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[[Category: Bisson, C]]
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[[Category: Baker PJ]]
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[[Category: Britton, K L]]
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[[Category: Bisson C]]
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[[Category: Eadsforth, T C]]
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[[Category: Britton KL]]
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[[Category: Hawkes, T R]]
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[[Category: Eadsforth TC]]
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[[Category: Rice, D W]]
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[[Category: Hawkes TR]]
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[[Category: Rodgers, H F]]
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[[Category: Rice DW]]
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[[Category: Sedelnikova, S E]]
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[[Category: Rodgers HF]]
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[[Category: Viner, R C]]
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[[Category: Sedelnikova SE]]
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[[Category: Dehydratase]]
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[[Category: Viner RC]]
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[[Category: Herbicide development]]
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[[Category: Histidine biosynthesis]]
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[[Category: Inhibitor complex]]
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[[Category: Lyase]]
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Current revision

A. thaliana IGPD2 in complex with the triazole-phosphonate inhibitor, (R)-C348, to 1.36A resolution

PDB ID 5elw

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