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5elx

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Current revision (06:33, 5 July 2023) (edit) (undo)
 
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<StructureSection load='5elx' size='340' side='right'caption='[[5elx]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
<StructureSection load='5elx' size='340' side='right'caption='[[5elx]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5elx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ELX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ELX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5elx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_YJM789 Saccharomyces cerevisiae YJM789]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ELX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ELX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=M2A:[(2~{R},3~{R},4~{R},5~{S})-2-(6-AMINOPURIN-9-YL)-4-OXIDANYL-5-[[OXIDANYL(PHOSPHONOOXY)PHOSPHORYL]OXYMETHYL]OXOLAN-3-YL]+2-(METHYLAMINO)BENZOATE'>M2A</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3pey|3pey]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=M2A:[(2~{R},3~{R},4~{R},5~{S})-2-(6-AMINOPURIN-9-YL)-4-OXIDANYL-5-[[OXIDANYL(PHOSPHONOOXY)PHOSPHORYL]OXYMETHYL]OXOLAN-3-YL]+2-(METHYLAMINO)BENZOATE'>M2A</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DBP5, RAT8, SCY_5119 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=307796 Baker's yeast])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5elx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5elx OCA], [https://pdbe.org/5elx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5elx RCSB], [https://www.ebi.ac.uk/pdbsum/5elx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5elx ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5elx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5elx OCA], [http://pdbe.org/5elx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5elx RCSB], [http://www.ebi.ac.uk/pdbsum/5elx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5elx ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DBP5_YEAS7 DBP5_YEAS7]] ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription (By similarity).
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[https://www.uniprot.org/uniprot/DBP5_YEAST DBP5_YEAST] ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. Contributes to the blocking of bulk poly(A)+ mRNA export in ethanol-stressed cells. May also be involved in early transcription.<ref>PMID:9564047</ref> <ref>PMID:9564048</ref> <ref>PMID:10428971</ref> <ref>PMID:10610322</ref> <ref>PMID:10523319</ref> <ref>PMID:11350039</ref> <ref>PMID:12192043</ref> <ref>PMID:12686617</ref> <ref>PMID:15280434</ref> <ref>PMID:15574330</ref> <ref>PMID:15619606</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baker's yeast]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: RNA helicase]]
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[[Category: Saccharomyces cerevisiae YJM789]]
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[[Category: Merchant, M K]]
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[[Category: Merchant MK]]
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[[Category: Modis, Y]]
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[[Category: Modis Y]]
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[[Category: Adp]]
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[[Category: Fluorescent]]
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[[Category: Hydrolase]]
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[[Category: Mant]]
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[[Category: Nucleotide]]
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[[Category: Rna helicase]]
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Current revision

S. cerevisiae Dbp5 bound to RNA and mant-ADP BeF3

PDB ID 5elx

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