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Aldolase 3D structures

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Line 8: Line 8:
**[[1xfb]], [[1qo5]], [[2ald]], [[1ald]], [[5ky6]] – hFBPA – human<br />
**[[1xfb]], [[1qo5]], [[2ald]], [[1ald]], [[5ky6]] – hFBPA – human<br />
**[[1xdl]], [[1xdm]] – hFBPA (mutant)<br />
**[[1xdl]], [[1xdm]] – hFBPA (mutant)<br />
-
**[[1zah]], [[1fdj]], [[1ewd]], [[1ewe]], [[1ex5]], [[1ado]], [[5vy5]] - rFBPA – rabbit<br />
+
**[[1zah]], [[1fdj]], [[1ewd]], [[1ewe]], [[1ex5]], [[1ado]], [[5vy5]], [[7ka4]] - rFBPA – rabbit<br />
**[[3dfn]], [[3dfp]], [[3dfq]], [[3dft]], [[2bv4]], [[3b8d]], [[3bv4]], [[5f4x]] – rFBPA (mutant)<br />
**[[3dfn]], [[3dfp]], [[3dfq]], [[3dft]], [[2bv4]], [[3b8d]], [[3bv4]], [[5f4x]] – rFBPA (mutant)<br />
-
**[[6v20]] - rFBPA – Cryo EM<br />
+
**[[6v20]], [[7k9l]], [[7k9x]], [[7ka2]], [[7ka3]], [[7vdc]] - rFBPA – Cryo EM<br />
**[[1fba]] – FBPA – ''Drosophila melanogaster''<br />
**[[1fba]] – FBPA – ''Drosophila melanogaster''<br />
**[[1ojx]], [[1ok6]] – TptFBPA – ''Thermoproteus tenax''<br />
**[[1ojx]], [[1ok6]] – TptFBPA – ''Thermoproteus tenax''<br />
Line 32: Line 32:
**[[4d2j]], [[4tu1]], [[5tjs]] – TgFBPA – ''Toxoplasma gondii''<br />
**[[4d2j]], [[4tu1]], [[5tjs]] – TgFBPA – ''Toxoplasma gondii''<br />
**[[5u4n]] – FBPA – ''Neisseria gonorrhoeae''<br />
**[[5u4n]] – FBPA – ''Neisseria gonorrhoeae''<br />
 +
**[[6lnk]] – FBPA – ''Candida albicans''<br />
 +
**[[7b2n]] – FBPA – ''Chlamydomonas reinhardtii''<br />
 +
**[[7efs]] – FBPA – ''Artemisia sieversiana''<br />
*FBPA complex
*FBPA complex
Line 73: Line 76:
**[[3n9r]], [[3n9s]], [[3c52]], [[3c56]] - HpFBPA + inhibitor<br />
**[[3n9r]], [[3n9s]], [[3c52]], [[3c56]] - HpFBPA + inhibitor<br />
**[[3mmt]] – FBPA + FBP – ''Bartonella henselae''<br />
**[[3mmt]] – FBPA + FBP – ''Bartonella henselae''<br />
 +
**[[7nc7]] – BmFBPA + dihydroxyacetonephosphate – ''Bacillus methanolicus''<br />
 +
**[[7ncc]] – BmFBPA + imidazole + succinate derivativc<br />
 +
**[[7v6g]] - CaFBPA (mutant) + inhibitor<br />
 +
**[[7v6f]] - CaFBPA (mutant) + G3P<br />
*Fructose–6-phosphate aldolase
*Fructose–6-phosphate aldolase
-
**[[4s1f]] – EcF6PA 1 <br />
+
**[[1l6w]], [[4s1f]] – EcF6PA 1 <br />
-
**[[4rz4]], [[4rxg]], [[4rxf]] – EcF6PA 1 (mutant)<br />
+
**[[4rz4]], [[4rxg]], [[4rxf]], [[5zol]] – EcF6PA 1 (mutant)<br />
*Deoxyribose-phosphate aldolase
*Deoxyribose-phosphate aldolase
Line 86: Line 93:
**[[2a4a]] – DERA – ''Plasmodium yoelii''<br />
**[[2a4a]] – DERA – ''Plasmodium yoelii''<br />
**[[1vcv]] – DERA – ''Pyrobaculum aerophilum''<br />
**[[1vcv]] – DERA – ''Pyrobaculum aerophilum''<br />
-
**[[1p1x]], [[1ktn]], [[3npu]], [[3npv]], [[3npw]], [[3npx]], [[3nq2]], [[3nq8]], [[3nqv]], [[3nr0]], [[3q2d]] – EcDERA<br />
+
**[[1p1x]], [[1ktn]], [[3npu]], [[3npv]], [[3npw]], [[3npx]], [[3nq2]], [[3nq8]], [[3nqv]], [[3nr0]], [[3q2d]], [[6z9j]], [[7p75]] – EcDERA<br />
-
**[[5emu]], [[5el1]], [[5eky]] - EcDERA (mutant)<br />
+
**[[5emu]], [[5el1]], [[5eky]], [[6z9h]] - EcDERA (mutant)<br />
-
**[[1jcj]], [[1jcl]] – EcDERA (mutant) + reaction intermediate<br />
+
**[[1jcj]], [[1jcl]], [[7p76]] – EcDERA (mutant) + reaction intermediate<br />
 +
**[[6z9i]] - EcDERA (mutant) + G3P<br />
**[[1n7k]] – ApDERA – ''Aeropyrum pernix''<br />
**[[1n7k]] – ApDERA – ''Aeropyrum pernix''<br />
**[[1mzh]] – AaDERA - ''Aquifex aeolicus''<br />
**[[1mzh]] – AaDERA - ''Aquifex aeolicus''<br />
Line 98: Line 106:
**[[5c6m]] – DERA – ''Shewanella halifasensis''<br />
**[[5c6m]] – DERA – ''Shewanella halifasensis''<br />
**[[5c5y]], [[5c2x]] – DERA – ''Colwellia psychrerythraea''<br />
**[[5c5y]], [[5c2x]] – DERA – ''Colwellia psychrerythraea''<br />
-
**[[6msw]] – DERA (mutant) – ''Bacillus halodurans''<br />
+
**[[6d33]] – BhDERA – ''Bacillus halodurans''<br />
 +
**[[6msw]] – BhDERA (mutant) – ''Bacillus halodurans''<br />
-
*Dehydroneopterin aldolase
+
*Dihydroneopterin aldolase
**[[1sql]] – AtDHNPA + guanine <br />
**[[1sql]] – AtDHNPA + guanine <br />
Line 114: Line 123:
**[[5far]] – BcDHNPA + methylguanine – ''Bacillus cereus''<br />
**[[5far]] – BcDHNPA + methylguanine – ''Bacillus cereus''<br />
-
*HpcH/HpaI aldolase
+
*HpcH/HpaI aldolase or 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase or Metal-dependent pyruvate aldolase
**[[3qz6]] – HPA – ''Desulfitobacterium hafniense''<br />
**[[3qz6]] – HPA – ''Desulfitobacterium hafniense''<br />
Line 125: Line 134:
**[[6kkh]] – RcHHALD + oxalate <br />
**[[6kkh]] – RcHHALD + oxalate <br />
**[[6r62]] – HHALD + hydroxypyruvate – ''Sphingomonas wittichii''<br />
**[[6r62]] – HHALD + hydroxypyruvate – ''Sphingomonas wittichii''<br />
-
 
+
**[[4b5x]] – EcPyrA (mutant)<br />
-
*Sialic acid aldolase
+
**[[4b5s]] – EcPyrA + pyruvate + Co + Mg<br />
-
 
+
**[[4b5w]] – EcPyrA (mutant) + pyruvate + Co <br />
-
**[[3lbm]] – EcSAA <br />
+
**[[4b5t]] – EcPyrA + keto-butyrate + Co + Mg<br />
-
**[[3lcf]], [[3lcg]], [[3lch]], [[3lci]], [[3lcl]], [[2wnq]], [[2wo5]] - EcSAA (mutant)<br />
+
**[[4b5u]] – EcPyrA + succinic semialdehyde + Co + Mg<br />
-
**[[3lbc]] – EcSAA + L-arabinose<br />
+
**[[4b5v]] – EcPyrA + pyruvate + heptanedioate derivative + Mg<br />
-
**[[2wnn]] – EcSAA + pyruvate <br />
+
**[[tet8]] – AbHpai + Ca <br />
-
**[[2wnz]], [[2wkj]] - EcSAA (mutant) + pyruvate <br />
+
**[[7etd]] – AbHpai + Ca + Zn<br />
-
**[[2wpb]] - EcSAA (mutant) + pyruvate + inhibitor<br />
+
**[[7ete]] – AbHpai + Ca + Mg<br />
-
**[[3lcx]] - EcSAA L-KDO (mutant)<br />
+
**[[7etb]], [[7etf]] – AbHpai + pyruvate + Ca + Mn<br />
-
**[[3lcw]] - EcSAA L-KDO (mutant) + hydroxypyruvate <br />
+
**[[7et9]], [[7eta]], [[7etc]], [[7etg]], [[7eth]], [[7eti]] – AbHpai + pyruvate + Ca + Zn<br />
*Oxoadipate aldolase
*Oxoadipate aldolase
Line 147: Line 156:
**[[4lrs]], [[4lrt]] – OVA + acetaldehyde dehydrogenase – ''Thermomonospora curvata''<br />
**[[4lrs]], [[4lrt]] – OVA + acetaldehyde dehydrogenase – ''Thermomonospora curvata''<br />
-
*keto-deoxyphosphogluconate aldolase (KDPG)
+
*2-keto-3-deoxy-6-phosphogluconate aldolase (KDPG)
**[[3nzr]] – KDPG – ''Vibrio fischeri''<br />
**[[3nzr]] – KDPG – ''Vibrio fischeri''<br />
Line 157: Line 166:
**[[1fwr]] - EcKDPG (mutant)<br />
**[[1fwr]] - EcKDPG (mutant)<br />
**[[5xse]] - ZmKDPG – ''Zymomonas mobilis''<br />
**[[5xse]] - ZmKDPG – ''Zymomonas mobilis''<br />
 +
**[[8di1]] - KDPG – ''Tannerella forsythia''<br />
*KDPG complex
*KDPG complex
Line 164: Line 174:
**[[5xsf]] - ZmKDPG + pyruvate <br />
**[[5xsf]] - ZmKDPG + pyruvate <br />
**[[6ovi]] - KDPG + pyruvate derivative – ''Legionella pneumophila''<br />
**[[6ovi]] - KDPG + pyruvate derivative – ''Legionella pneumophila''<br />
 +
**[[6g3z]] – SsKDPG + KDPG - ''Sulfolobus solfataricus'' <br />
-
*keto-deoxygluconate aldolase (KDG)
+
*2-keto-3-deoxygluconate aldolase (KDG)
**[[2nuw]], [[2nux]] – SaKDG – ''Sulfolobus acidocaldarius''<br />
**[[2nuw]], [[2nux]] – SaKDG – ''Sulfolobus acidocaldarius''<br />
**[[2nuy]] – SaKDG + pyruvate <br />
**[[2nuy]] – SaKDG + pyruvate <br />
-
**[[1w37]] - SsDDPGA – ''Sulfolobus solfataricus''<br />
+
**[[1w37]] - SsDDPGA <br />
 +
**[[6gso]], [[6gt8]], [[6h2r]], [[6h7r]] – SsKDG (mutant)<br />
 +
**[[6h7s]] – SsKDG (mutant) + KDG<br />
 +
**[[6gv2]] – SsKDG (mutant) + KD-galactonate<br />
 +
**[[6g3z]] – SsKDG + KDPG<br />
**[[1w3i]] - SsKDG + pyruvate <br />
**[[1w3i]] - SsKDG + pyruvate <br />
 +
**[[6h2s]] - SsKDG (mutant) + pyruvate <br />
**[[1w3n]] - SsKDG + gluconate<br />
**[[1w3n]] - SsKDG + gluconate<br />
**[[1w3t]] - SsKDG + gluconate + pyruvate <br />
**[[1w3t]] - SsKDG + gluconate + pyruvate <br />
**[[2yda]] – KDG – ''Vibrio fischeri''
**[[2yda]] – KDG – ''Vibrio fischeri''
-
*Deoxyphosphooctonate aldolase
+
*Deoxyphosphooctonate aldolase or 2-dehydro-3-deoxy-6-phosphooctonate aldolase
**See [[Kdo-8-phosphate synthase]]
**See [[Kdo-8-phosphate synthase]]
-
*Deoxyphosphogalactonate aldolase
+
*2-dehydro-3-deoxy-6-phosphogalactonate aldolase
**[[2v81]] – EcKDPGAL<br />
**[[2v81]] – EcKDPGAL<br />
Line 195: Line 211:
**[[6bdd]] – KaALD + heme – ''Kordia algicida''<br />
**[[6bdd]] – KaALD + heme – ''Kordia algicida''<br />
**[[6bde]] – KaALD (mutant) + heme <br />
**[[6bde]] – KaALD (mutant) + heme <br />
 +
 +
*Sulfofructosephosphate aldolase
 +
 +
**[[7ag7]] – SeSFP – ''Salmonella enterica''<br />
 +
**[[7ne2]] – SeSFP +SFP/DHAP <br />
 +
**[[7ag1]] – EcSFP <br />
*Phospho-2-dehydro-3-deoxyheptonate aldolase
*Phospho-2-dehydro-3-deoxyheptonate aldolase
Line 207: Line 229:
**[[3ocr]] – ALDII – ''Pseudomonas syringae''<br />
**[[3ocr]] – ALDII – ''Pseudomonas syringae''<br />
 +
**[[7v8t]] – ALDII – ''Pseudomonas aeruginosa''<br />
**[[2vws]] – EcALDII<br />
**[[2vws]] – EcALDII<br />
**[[2vwt]] – EcALDII + pyruvate <br />
**[[2vwt]] – EcALDII + pyruvate <br />
Line 248: Line 271:
**[[6btd]] – BtFPA – ''Bacillus thuringiensis''<br />
**[[6btd]] – BtFPA – ''Bacillus thuringiensis''<br />
**[[6btg]] – BtFPA + DHAP <br />
**[[6btg]] – BtFPA + DHAP <br />
 +
**[7x78f]] – FPA – ''Klebsiella pneumoniae''<br />
-
*Sphingosin-1-phosphate aldolase
+
*Sphingosine-1-phosphate Aldolase or Sphingosine-1-phosphate lyase
**[[3mc6]] – ySCDPL1 (mutant) <br />
**[[3mc6]] – ySCDPL1 (mutant) <br />
 +
**[[4q6r]] – hSPL + inhibitor<br />
*Rhamnulose-1-phosphate aldolase
*Rhamnulose-1-phosphate aldolase
Line 258: Line 283:
**[[2v9g]], [[2v9o]], [[2uyu]], [[2uyv]], [[2v9e]], [[2v9f]], [[2v9i]], [[2v9l]], [[2v9m]], [[2v9n]], [[2v29]], [[2v2a]], [[2v2b]], [[1ojr]] – EcRPA (mutant)<br />
**[[2v9g]], [[2v9o]], [[2uyu]], [[2uyv]], [[2v9e]], [[2v9f]], [[2v9i]], [[2v9l]], [[2v9m]], [[2v9n]], [[2v29]], [[2v2a]], [[2v2b]], [[1ojr]] – EcRPA (mutant)<br />
-
*Oxoglutarate aldolase
+
*4-hydroxy-2-oxoglutarate aldolase
**[[3s5n]], [[3s5o]] - hOGA<br />
**[[3s5n]], [[3s5o]] - hOGA<br />
Line 268: Line 293:
**[[3gkf]] – EcLsrFA<br />
**[[3gkf]] – EcLsrFA<br />
**[[3glc]], [[3gnd]] – EcLsrFA + ribose derivative<br />
**[[3glc]], [[3gnd]] – EcLsrFA + ribose derivative<br />
 +
**[[4p2v]] – EcLsrF (mutant) + hydroxt dioxopentyl dihydrogen phosphate <br />
* Hydroxyaspartate aldolase
* Hydroxyaspartate aldolase
Line 284: Line 310:
**[[4v15]] – ThrA – ''Achromobacter xylosoxidans''<br />
**[[4v15]] – ThrA – ''Achromobacter xylosoxidans''<br />
**[[5vye]] – PpThrA + pyridoxime derivative<br />
**[[5vye]] – PpThrA + pyridoxime derivative<br />
 +
**[[7k34]] – ThrA – ''Pseudomonas fluorescens''<br />
*Phenylserine aldolase
*Phenylserine aldolase
Line 289: Line 316:
**[[1v72]] – PpFSA<br />
**[[1v72]] – PpFSA<br />
**[[1j2w]], [[1ub3]] - TtALD<br />
**[[1j2w]], [[1ub3]] - TtALD<br />
- 
-
*Metal-dependent pyruvate aldolase 2
 
- 
-
**[[4b5x]] – EcPyrA (mutant)<br />
 
-
**[[4b5s]] – EcPyrA + pyruvate + Co + Mg<br />
 
-
**[[4b5w]] – EcPyrA (mutant) + pyruvate + Co <br />
 
-
**[[4b5t]] – EcPyrA + keto-butyrate + Co + Mg<br />
 
-
**[[4b5u]] – EcPyrA + succinic semialdehyde + Co + Mg<br />
 
-
**[[4b5v]] – EcPyrA + pyruvate + heptanedioate derivative + Mg
 
*Retro-aldolase
*Retro-aldolase
-
**[[3nxf]], [[3o6y]], [[3ud6]], [[4pek]], [[4pej]], [[4pa8]] – RA – artificial gene<br />
+
**[[3b5l]], [[3hoj]], [[3nxf]], [[3o6y]], [[3ud6]], [[4a29]], [[4pek]], [[4pej]], [[4pa8]], [[7f1i]], [[7f1j]], [[7f1k]], [[7f1l]] – RA – artificial gene<br />
-
**[[4ou1]] – SsRA<br />
+
**[[4ou1]], [[4a2r]], [[4a2s]], [[4pa8]], [[5aou]], [[6tfa]] – SsRA<br />
 +
**[[5an7]] – SsRA + inhibitor<br />
 +
**[[4cdl]] – PpRA + inhibitor<br />
*17-alpha-hydroxyprogesterone aldolase (steroid 17-alpha-hydroxylase /17,20 lyase) see [[Cytochrome P450]]
*17-alpha-hydroxyprogesterone aldolase (steroid 17-alpha-hydroxylase /17,20 lyase) see [[Cytochrome P450]]
 +
 +
*Sialic acid aldolase see [[N-acetylneuraminate lyase]]
}}
}}
[[Category: Topic Page]]
[[Category: Topic Page]]

Current revision

3D structures of Aldolase

Updated on 10-July-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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