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1v0f

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==ENDOSIALIDASE OF BACTERIOPHAGE K1F IN COMPLEX WITH OLIGOMERIC ALPHA-2,8-SIALIC ACID==
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<StructureSection load='1v0f' size='340' side='right' caption='[[1v0f]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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==Endosialidase of Bacteriophage K1F in complex with oligomeric alpha-2,8-sialic acid==
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<StructureSection load='1v0f' size='340' side='right'caption='[[1v0f]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1v0f]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_k1f Enterobacteria phage k1f]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V0F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V0F FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1v0f]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_K1F Escherichia phage K1F]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V0F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1v0e|1v0e]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v0f OCA], [https://pdbe.org/1v0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v0f RCSB], [https://www.ebi.ac.uk/pdbsum/1v0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v0f ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endo-alpha-sialidase Endo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.129 3.2.1.129] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v0f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v0f RCSB], [http://www.ebi.ac.uk/pdbsum/1v0f PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FIBER_BPK1F FIBER_BPK1F] Responsible for initial absorption of the phage to the host bacterium. Degrades the alpha-2,8-linked polysialic acid K1 capsule by cleaving within the polymer chain of polysialic acid.<ref>PMID:20096705</ref> <ref>PMID:3546309</ref> The C-terminal chaperone protein mediates homotrimerization and proper folding of the catalytic endo-N trimer.<ref>PMID:12556457</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1v0f" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Endo-alpha-sialidase]]
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[[Category: Escherichia phage K1F]]
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[[Category: Enterobacteria phage k1f]]
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[[Category: Large Structures]]
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[[Category: Dickmanns, A]]
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[[Category: Dickmanns A]]
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[[Category: Ficner, R]]
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[[Category: Ficner R]]
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[[Category: Gerady-Schahn, R]]
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[[Category: Gerady-Schahn R]]
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[[Category: Muehlenhoff, M]]
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[[Category: Muehlenhoff M]]
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[[Category: Stummeyer, K]]
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[[Category: Stummeyer K]]
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[[Category: Endosialidase]]
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[[Category: Glycosidase]]
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[[Category: Hydrolase]]
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[[Category: Polysialic acid degradation]]
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Current revision

Endosialidase of Bacteriophage K1F in complex with oligomeric alpha-2,8-sialic acid

PDB ID 1v0f

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