1v3p
From Proteopedia
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| - | [[Image:1v3p.gif|left|200px]]<br /><applet load="1v3p" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1v3p, resolution 2.3Å" /> | ||
| - | '''Crystal structure of d(GCGAGAGC): the DNA octaplex structure with I-motif of G-quartet'''<br /> | ||
| - | == | + | ==Crystal structure of d(GCGAGAGC): the DNA octaplex structure with I-motif of G-quartet== |
| + | <StructureSection load='1v3p' size='340' side='right'caption='[[1v3p]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1v3p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V3P FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C38:5-IODO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>C38</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v3p OCA], [https://pdbe.org/1v3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v3p RCSB], [https://www.ebi.ac.uk/pdbsum/1v3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v3p ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
Recent genomic analyses revealed many kinds of tandem repeats of specific sequences. Some of them are related to genetic diseases, but their biological functions and structures are still unknown. Two X-ray structures of a short DNA fragment d(gcGA[G]1Agc) show that four base-intercalated duplexes are assembled to form an octaplex at a low K+ concentration, in which the eight G5 residues form a stacked double G-quartet in the central part. At a higher K+ concentration, however, the octaplex is split into just two halves. These structural features suggest a folding process of eight tandem repeats of d(ccGA[G]4Agg), according to a double Greek-key motif. Such a packaging of the repeats could facilitate slippage of a certain sequence during DNA replication, to induce increase or decrease of the repeats. | Recent genomic analyses revealed many kinds of tandem repeats of specific sequences. Some of them are related to genetic diseases, but their biological functions and structures are still unknown. Two X-ray structures of a short DNA fragment d(gcGA[G]1Agc) show that four base-intercalated duplexes are assembled to form an octaplex at a low K+ concentration, in which the eight G5 residues form a stacked double G-quartet in the central part. At a higher K+ concentration, however, the octaplex is split into just two halves. These structural features suggest a folding process of eight tandem repeats of d(ccGA[G]4Agg), according to a double Greek-key motif. Such a packaging of the repeats could facilitate slippage of a certain sequence during DNA replication, to induce increase or decrease of the repeats. | ||
| - | + | Crystal structures of a DNA octaplex with I-motif of G-quartets and its splitting into two quadruplexes suggest a folding mechanism of eight tandem repeats.,Kondo J, Adachi W, Umeda S, Sunami T, Takenaka A Nucleic Acids Res. 2004 May 7;32(8):2541-9. Print 2004. PMID:15133122<ref>PMID:15133122</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 1v3p" style="background-color:#fffaf0;"></div> |
| - | [[Category: Kondo | + | == References == |
| - | [[Category: Sunami | + | <references/> |
| - | [[Category: Takenaka | + | __TOC__ |
| - | [[Category: Umeda | + | </StructureSection> |
| - | + | [[Category: Large Structures]] | |
| - | + | [[Category: Kondo J]] | |
| - | + | [[Category: Sunami T]] | |
| - | + | [[Category: Takenaka A]] | |
| - | + | [[Category: Umeda S]] | |
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Current revision
Crystal structure of d(GCGAGAGC): the DNA octaplex structure with I-motif of G-quartet
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