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1lj2

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[[Image:1lj2.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lj2 OCA], [http://www.ebi.ac.uk/pdbsum/1lj2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lj2 RCSB]</span>
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'''Recognition of eIF4G by Rotavirus NSP3 reveals a basis for mRNA circularization'''
'''Recognition of eIF4G by Rotavirus NSP3 reveals a basis for mRNA circularization'''
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[[Category: Burley, S K.]]
[[Category: Burley, S K.]]
[[Category: Groft, C M.]]
[[Category: Groft, C M.]]
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[[Category: closed loop]]
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[[Category: Closed loop]]
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[[Category: coiled coil]]
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[[Category: Coiled coil]]
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[[Category: eif4g]]
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[[Category: Eif4g]]
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[[Category: homodimer]]
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[[Category: Homodimer]]
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[[Category: mrna]]
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[[Category: Mrna]]
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[[Category: nsp3]]
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[[Category: Nsp3]]
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[[Category: rotavirus]]
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[[Category: Rotavirus]]
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[[Category: translation]]
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[[Category: Translation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:58:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:03:23 2008''
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Revision as of 20:58, 2 May 2008

Image:1lj2.gif

Template:STRUCTURE 1lj2

Recognition of eIF4G by Rotavirus NSP3 reveals a basis for mRNA circularization


Overview

Rotaviruses, segmented double-stranded RNA viruses, co-opt the eukaryotic translation machinery with the aid of nonstructural protein 3 (NSP3), a rotaviral functional homolog of the cellular poly(A) binding protein (PABP). NSP3 binds to viral mRNA 3' consensus sequences and circularizes mRNA via interactions with eIF4G. Here, we present the X-ray structure of the C-terminal domain of NSP3 (NSP3-C) recognizing a fragment of eIF4GI. Homodimerization of NSP3-C yields a symmetric, elongated, largely alpha-helical structure with two hydrophobic eIF4G binding pockets at the dimer interface. Site-directed mutagenesis and isothermal titration calorimetry documented that NSP3 and PABP use analogous eIF4G recognition strategies, despite marked differences in tertiary structure.

About this Structure

1LJ2 is a Protein complex structure of sequences from Simian rotavirus a/sa11. Full crystallographic information is available from OCA.

Reference

Recognition of eIF4G by rotavirus NSP3 reveals a basis for mRNA circularization., Groft CM, Burley SK, Mol Cell. 2002 Jun;9(6):1273-83. PMID:12086624 Page seeded by OCA on Fri May 2 23:58:01 2008

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