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3odl

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Current revision (07:58, 12 July 2023) (edit) (undo)
 
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<StructureSection load='3odl' size='340' side='right'caption='[[3odl]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
<StructureSection load='3odl' size='340' side='right'caption='[[3odl]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3odl]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ODL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3odl]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Tolypocladium_inflatum Tolypocladium inflatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ODL FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene>, <scene name='pdbligand=YYA:2,4,5-TRIDEOXY-2-(METHYLAMINO)-4-[(2Z)-PENTA-2,4-DIEN-1-YL]-L-XYLONIC+ACID'>YYA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3odi|3odi]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene>, <scene name='pdbligand=YYA:2,4,5-TRIDEOXY-2-(METHYLAMINO)-4-[(2Z)-PENTA-2,4-DIEN-1-YL]-L-XYLONIC+ACID'>YYA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPIA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3odl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odl OCA], [https://pdbe.org/3odl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3odl RCSB], [https://www.ebi.ac.uk/pdbsum/3odl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3odl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3odl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odl OCA], [https://pdbe.org/3odl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3odl RCSB], [https://www.ebi.ac.uk/pdbsum/3odl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3odl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PPIA_HUMAN PPIA_HUMAN]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
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[https://www.uniprot.org/uniprot/PPIA_HUMAN PPIA_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Tolypocladium inflatum]]
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[[Category: Benz, J]]
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[[Category: Benz J]]
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[[Category: Hennig, M]]
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[[Category: Hennig M]]
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[[Category: Kuglstatter, A]]
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[[Category: Kuglstatter A]]
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[[Category: Stihle, M]]
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[[Category: Stihle M]]
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[[Category: Calcineurin]]
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[[Category: Calcineurin inhibition]]
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[[Category: Cyclosporin]]
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[[Category: Immunosuppressant]]
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[[Category: Isomerase-immunosuppressant complex]]
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[[Category: Psoriasis]]
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[[Category: Voclosporin]]
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Current revision

Crystal structure of cyclophilin A in complex with Voclosporin Z-ISA247

PDB ID 3odl

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