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5en4

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==Complex of 17-beta-hydroxysteroid dehydrogenase type 14 with inhibitor.==
==Complex of 17-beta-hydroxysteroid dehydrogenase type 14 with inhibitor.==
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<StructureSection load='5en4' size='340' side='right' caption='[[5en4]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
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<StructureSection load='5en4' size='340' side='right'caption='[[5en4]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5en4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EN4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5en4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EN4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5Q6:[2,3-BIS(OXIDANYL)PHENYL]-[6-(2-FLUORANYL-3-OXIDANYL-PHENYL)PYRIDIN-2-YL]METHANONE'>5Q6</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.52&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yde|1yde]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5Q6:[2,3-BIS(OXIDANYL)PHENYL]-[6-(2-FLUORANYL-3-OXIDANYL-PHENYL)PYRIDIN-2-YL]METHANONE'>5Q6</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5en4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5en4 OCA], [http://pdbe.org/5en4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5en4 RCSB], [http://www.ebi.ac.uk/pdbsum/5en4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5en4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5en4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5en4 OCA], [https://pdbe.org/5en4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5en4 RCSB], [https://www.ebi.ac.uk/pdbsum/5en4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5en4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DHB14_HUMAN DHB14_HUMAN]] Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).<ref>PMID:17067289</ref>
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[https://www.uniprot.org/uniprot/DHB14_HUMAN DHB14_HUMAN] Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).<ref>PMID:17067289</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5en4" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5en4" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bertoletti, N]]
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[[Category: Homo sapiens]]
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[[Category: Braun, F]]
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[[Category: Large Structures]]
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[[Category: Heine, A]]
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[[Category: Bertoletti N]]
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[[Category: Klebe, G]]
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[[Category: Braun F]]
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[[Category: Marchais-Oberwinkler, S]]
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[[Category: Heine A]]
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[[Category: Inhibitor complex]]
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[[Category: Klebe G]]
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[[Category: Oxidoreductase]]
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[[Category: Marchais-Oberwinkler S]]
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[[Category: Steroid dehydrogenase]]
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Current revision

Complex of 17-beta-hydroxysteroid dehydrogenase type 14 with inhibitor.

PDB ID 5en4

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