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1lj9
From Proteopedia
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[[Image:1lj9.gif|left|200px]] | [[Image:1lj9.gif|left|200px]] | ||
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'''The crystal structure of the transcriptional regulator SlyA''' | '''The crystal structure of the transcriptional regulator SlyA''' | ||
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[[Category: Wu, R Y.]] | [[Category: Wu, R Y.]] | ||
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Revision as of 20:58, 2 May 2008
The crystal structure of the transcriptional regulator SlyA
Overview
The crystal structure of a SlyA transcriptional regulator at 1.6 A resolution is presented, and structural relationships between members of the MarR/SlyA family are discussed. The SlyA family, which includes SlyA, Rap, Hor, and RovA proteins, is widely distributed in bacterial and archaeal genomes. Current evidence suggests that SlyA-like factors act as repressors, activators, and modulators of gene transcription. These proteins have been shown to up-regulate the expression of molecular chaperones, acid-resistance proteins, and cytolysin, and down-regulate several biosynthetic enzymes. The structure of SlyA from Enterococcus faecalis, determined as a part of an ongoing structural genomics initiative (www.mcsg.anl.gov), revealed the same winged helix DNA-binding motif that was recently found in the MarR repressor from Escherichia coli and the MexR repressor from Pseudomonas aeruginosa, a sequence homologue of MarR. Phylogenetic analysis of the MarR/SlyA family suggests that Sly is placed between the SlyA and MarR subfamilies and shows significant sequence similarity to members of both subfamilies.
About this Structure
1LJ9 is a Single protein structure of sequence from Enterococcus faecalis. Full crystallographic information is available from OCA.
Reference
Crystal structure of Enterococcus faecalis SlyA-like transcriptional factor., Wu RY, Zhang RG, Zagnitko O, Dementieva I, Maltzev N, Watson JD, Laskowski R, Gornicki P, Joachimiak A, J Biol Chem. 2003 May 30;278(22):20240-4. Epub 2003 Mar 20. PMID:12649270 Page seeded by OCA on Fri May 2 23:58:21 2008
