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5f08

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==Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium tuberculosis in complex with compound 14 at 1.92A resolution==
==Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium tuberculosis in complex with compound 14 at 1.92A resolution==
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<StructureSection load='5f08' size='340' side='right' caption='[[5f08]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
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<StructureSection load='5f08' size='340' side='right'caption='[[5f08]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5f08]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F08 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5f08]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_CDC1551 Mycobacterium tuberculosis CDC1551]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F08 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5TG:~{TERT}-BUTYL+~{N}-METHYL-~{N}-[[4-[4-(3-OXIDANYLIDENE-3-PYRROLIDIN-1-YL-PROPYL)PIPERIDIN-1-YL]PHENYL]METHYL]CARBAMATE'>5TG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f08 OCA], [http://pdbe.org/5f08 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f08 RCSB], [http://www.ebi.ac.uk/pdbsum/5f08 PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5TG:~{TERT}-BUTYL+~{N}-METHYL-~{N}-[[4-[4-(3-OXIDANYLIDENE-3-PYRROLIDIN-1-YL-PROPYL)PIPERIDIN-1-YL]PHENYL]METHYL]CARBAMATE'>5TG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f08 OCA], [https://pdbe.org/5f08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f08 RCSB], [https://www.ebi.ac.uk/pdbsum/5f08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f08 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ETHR_MYCTO ETHR_MYCTO]] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).
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[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5f08" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5f08" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Complement C3 3D structures|Complement C3 3D structures]]
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*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Abell, C]]
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[[Category: Large Structures]]
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[[Category: Blaszczyk, M]]
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[[Category: Mycobacterium tuberculosis CDC1551]]
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[[Category: Blundell, T L]]
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[[Category: Abell C]]
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[[Category: Nikiforov, P O]]
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[[Category: Blaszczyk M]]
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[[Category: Surade, S]]
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[[Category: Blundell TL]]
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[[Category: Ethr]]
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[[Category: Nikiforov PO]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Surade S]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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Current revision

Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium tuberculosis in complex with compound 14 at 1.92A resolution

PDB ID 5f08

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