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5f0s

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==Crystal structure of C-terminal domain of the human DNA primase large subunit with bound DNA template/RNA primer and manganese ion==
==Crystal structure of C-terminal domain of the human DNA primase large subunit with bound DNA template/RNA primer and manganese ion==
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<StructureSection load='5f0s' size='340' side='right' caption='[[5f0s]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='5f0s' size='340' side='right'caption='[[5f0s]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5f0s]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F0S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5f0s]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F0S FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5f0q|5f0q]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f0s OCA], [https://pdbe.org/5f0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f0s RCSB], [https://www.ebi.ac.uk/pdbsum/5f0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f0s ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRIM2, PRIM2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f0s OCA], [http://pdbe.org/5f0s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f0s RCSB], [http://www.ebi.ac.uk/pdbsum/5f0s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f0s ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PRI2_HUMAN PRI2_HUMAN]] DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.
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[https://www.uniprot.org/uniprot/PRI2_HUMAN PRI2_HUMAN] DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5f0s" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5f0s" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Babayeva, N D]]
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[[Category: Large Structures]]
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[[Category: Baranovskiy, A G]]
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[[Category: Babayeva ND]]
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[[Category: Tahirov, T H]]
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[[Category: Baranovskiy AG]]
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[[Category: Dna]]
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[[Category: Tahirov TH]]
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[[Category: Dna primase]]
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[[Category: Initiation site]]
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[[Category: Iron-sulfur cluster]]
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[[Category: Large subunit]]
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[[Category: Manganese]]
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[[Category: Primer]]
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[[Category: Replication-dna-rna complex]]
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[[Category: Rna]]
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[[Category: Template]]
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[[Category: Tranferase-dna-rna complex]]
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[[Category: Triphosphate]]
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Current revision

Crystal structure of C-terminal domain of the human DNA primase large subunit with bound DNA template/RNA primer and manganese ion

PDB ID 5f0s

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