Neutrophil gelatinase-associated lipocalin
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | <scene name='59/596433/Cv/ | + | <scene name='59/596433/Cv/4'>NGAL binds siderophores with cation-π interactions and an Fe+3 ion</scene> like carboxymycobactin or enterobactin<ref>PMID:15642259</ref>. Water molecules are shown as red spheres. |
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*Neutrophil gelatinase-associated lipocalin | *Neutrophil gelatinase-associated lipocalin | ||
| - | **[[1dfv]], [[1qqs]], [[ | + | **[[1dfv]], [[1qqs]], [[3bx8]], [[6gqz]], [[6z6z]] – hNGAL – human <br /> |
| - | **[[3dtq]], [[5jr8]], [[5mhh]] – hNGAL (mutant)<br /> | + | **[[3dtq]], [[5jr8]], [[5mhh]], [[6o5d]], [[6qmu]] – hNGAL (mutant)<br /> |
**[[1ngl]] – hNGAL - NMR<br /> | **[[1ngl]] – hNGAL - NMR<br /> | ||
**[[2k23]] – NGAL – rat - NMR<br /> | **[[2k23]] – NGAL – rat - NMR<br /> | ||
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**[[3pec]], [[3ped]] – hNGAL + Fe+3 + carboxymycobactin<br /> | **[[3pec]], [[3ped]] – hNGAL + Fe+3 + carboxymycobactin<br /> | ||
**[[1x71]], [[1x89]], [[1x8u]] – hNGAL (mutant) + Fe+3 + carboxymycobactin<br /> | **[[1x71]], [[1x89]], [[1x8u]] – hNGAL (mutant) + Fe+3 + carboxymycobactin<br /> | ||
| - | **[[3by0]], [[3cbc]], [[3cmp]], [[3hwd]], [[3hwf]], [[3hwg]], [[3i0a]], [[3k3l]], [[3t1d]], [[3u0d]], [ | + | **[[3by0]], [[3cbc]], [[3cmp]], [[3hwd]], [[3hwf]], [[3hwg]], [[3i0a]], [[3k3l]], [[3t1d]], [[3u0d]], [6o5d]] – hNGAL (mutant) + Fe+3 + enterobactin<br /> |
**[[4zfx]] – hNGAL + actinide + enterobactin<br /> | **[[4zfx]] – hNGAL + actinide + enterobactin<br /> | ||
**[[4k19]] – hNGAL (mutant) + Fe+3 + fluvibactin<br /> | **[[4k19]] – hNGAL (mutant) + Fe+3 + fluvibactin<br /> | ||
**[[3tf6]] – hNGAL (mutant) + Eu+2+ enterobactin<br /> | **[[3tf6]] – hNGAL (mutant) + Eu+2+ enterobactin<br /> | ||
| + | **[[6gr0]] – hNGAL + Ga+3 + oxidanyl derivative<br /> | ||
**[[3fw4]], [[3fw5]] – hNGAL (mutant) + Fe+3 + catechol derivative<br /> | **[[3fw4]], [[3fw5]] – hNGAL (mutant) + Fe+3 + catechol derivative<br /> | ||
**[[5nkn]] – hNGAL + colchicine<br /> | **[[5nkn]] – hNGAL + colchicine<br /> | ||
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**[[4qae]] – hNGAL (mutant) + hepcidin<br /> | **[[4qae]] – hNGAL (mutant) + hepcidin<br /> | ||
**[[3bx7]] – hNGAL + CTLA-4<br /> | **[[3bx7]] – hNGAL + CTLA-4<br /> | ||
| + | **[[6z2c]] – hNGAL + transition state analog<br /> | ||
**[[4mvi]], [[4mvk]], [[4mvl]] – hNGAL (mutant) + beta-APP40<br /> | **[[4mvi]], [[4mvk]], [[4mvl]] – hNGAL (mutant) + beta-APP40<br /> | ||
| + | **[[6s8v]] – hNGAL + h4F2HC<br /> | ||
| + | **[[6sua]] – hNGAL (mutant) + m4F2HC<br /> | ||
**[[3u9p]] – mNGAL + antibody<br /> | **[[3u9p]] – mNGAL + antibody<br /> | ||
Current revision
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3D structures of neutrophil gelatinase-associated lipocalin
Updated on 16-July-2023
References
- ↑ Friedl A, Stoesz SP, Buckley P, Gould MN. Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression. Histochem J. 1999 Jul;31(7):433-41. PMID:10475571
- ↑ Dartt DA. Tear lipocalin: structure and function. Ocul Surf. 2011 Jul;9(3):126-38. PMID:21791187
- ↑ Viau A, El Karoui K, Laouari D, Burtin M, Nguyen C, Mori K, Pillebout E, Berger T, Mak TW, Knebelmann B, Friedlander G, Barasch J, Terzi F. Lipocalin 2 is essential for chronic kidney disease progression in mice and humans. J Clin Invest. 2010 Nov;120(11):4065-76. doi: 10.1172/JCI42004. PMID:20921623 doi:http://dx.doi.org/10.1172/JCI42004
- ↑ Holmes MA, Paulsene W, Jide X, Ratledge C, Strong RK. Siderocalin (Lcn 2) also binds carboxymycobactins, potentially defending against mycobacterial infections through iron sequestration. Structure. 2005 Jan;13(1):29-41. PMID:15642259 doi:10.1016/j.str.2004.10.009
