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5f8t
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5f8t is ON HOLD Authors: Xu, M., Jiang, L., Xu, P., Luo, Z., Andreasen, P., Huang, M. Description: The crystal structure of human Plasma Kallikrein...) |
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| - | '''Unreleased structure''' | ||
| - | The entry 5f8t is | + | ==The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2== |
| + | <StructureSection load='5f8t' size='340' side='right'caption='[[5f8t]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5f8t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4zj5 4zj5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F8T FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MRZ:PIPERIDINE-1-CARBOXIMIDAMIDE'>MRZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f8t OCA], [https://pdbe.org/5f8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f8t RCSB], [https://www.ebi.ac.uk/pdbsum/5f8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f8t ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:[https://omim.org/entry/612423 612423]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. | ||
| - | + | ==See Also== | |
| - | + | *[[Kallikrein 3D structures|Kallikrein 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Synthetic construct]] |
| - | [[Category: Huang | + | [[Category: Andreasen P]] |
| - | [[Category: Jiang | + | [[Category: Huang M]] |
| - | [[Category: Luo | + | [[Category: Jiang L]] |
| + | [[Category: Luo Z]] | ||
| + | [[Category: Xu M]] | ||
| + | [[Category: Xu P]] | ||
Current revision
The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2
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Categories: Homo sapiens | Large Structures | Synthetic construct | Andreasen P | Huang M | Jiang L | Luo Z | Xu M | Xu P
