This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5fdx
From Proteopedia
(Difference between revisions)
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
==Structure of DDR1 receptor tyrosine kinase in complex with D2164 inhibitor at 2.65 Angstroms resolution.== | ==Structure of DDR1 receptor tyrosine kinase in complex with D2164 inhibitor at 2.65 Angstroms resolution.== | ||
| - | <StructureSection load='5fdx' size='340' side='right' caption='[[5fdx]], [[Resolution|resolution]] 2.65Å' scene=''> | + | <StructureSection load='5fdx' size='340' side='right'caption='[[5fdx]], [[Resolution|resolution]] 2.65Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5fdx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FDX OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5fdx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FDX FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5X1:3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-~{N}-[(4~{R})-4-METHYL-2-PYRIMIDIN-5-YL-3,4-DIHYDRO-1~{H}-ISOQUINOLIN-7-YL]-5-(TRIFLUOROMETHYL)BENZAMIDE'>5X1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5X1:3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-~{N}-[(4~{R})-4-METHYL-2-PYRIMIDIN-5-YL-3,4-DIHYDRO-1~{H}-ISOQUINOLIN-7-YL]-5-(TRIFLUOROMETHYL)BENZAMIDE'>5X1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fdx OCA], [https://pdbe.org/5fdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fdx RCSB], [https://www.ebi.ac.uk/pdbsum/5fdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fdx ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DDR1_HUMAN DDR1_HUMAN] | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Epithelial discoidin domain-containing receptor|Epithelial discoidin domain-containing receptor]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Bartual SG]] |
| - | [[Category: | + | [[Category: Borkowska O]] |
| - | [[Category: | + | [[Category: Bountra C]] |
| - | [[Category: Burgess-Brown | + | [[Category: Bullock A]] |
| - | [[Category: Chaikuad | + | [[Category: Burgess-Brown N]] |
| - | [[Category: Chalk | + | [[Category: Chaikuad A]] |
| - | [[Category: | + | [[Category: Chalk R]] |
| - | + | [[Category: Ding K]] | |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: | + | [[Category: Kopec J]] |
| - | [[Category: | + | [[Category: Kupinska K]] |
| - | [[Category: Mahajan | + | [[Category: Mahajan P]] |
| - | [[Category: Mukhopadhyay | + | [[Category: Mukhopadhyay S]] |
| - | [[Category: Newman | + | [[Category: Newman J]] |
| - | [[Category: | + | [[Category: Pinkas DM]] |
| - | + | [[Category: Sorell F]] | |
| - | [[Category: Sorell | + | [[Category: Strain-Damerell C]] |
| - | [[Category: Strain-Damerell | + | [[Category: Tallant C]] |
| - | [[Category: Tallant | + | [[Category: Talon R]] |
| - | [[Category: Talon | + | [[Category: Wang Z]] |
| - | [[Category: | + | [[Category: Williams E]] |
| - | [[Category: Williams | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Structure of DDR1 receptor tyrosine kinase in complex with D2164 inhibitor at 2.65 Angstroms resolution.
| |||||||||||
Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bartual SG | Borkowska O | Bountra C | Bullock A | Burgess-Brown N | Chaikuad A | Chalk R | Ding K | Edwards AM | Kopec J | Kupinska K | Mahajan P | Mukhopadhyay S | Newman J | Pinkas DM | Sorell F | Strain-Damerell C | Tallant C | Talon R | Wang Z | Williams E | Von Delft F
