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5fg6
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the bromodomain of human BRD1 (BRPF2) in complex with OF-1 chemical probe== | |
| + | <StructureSection load='5fg6' size='340' side='right'caption='[[5fg6]], [[Resolution|resolution]] 1.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5fg6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FG6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FG6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5XE:4-BROMANYL-~{N}-(6-METHOXY-1,3-DIMETHYL-2-OXIDANYLIDENE-BENZIMIDAZOL-5-YL)-2-METHYL-BENZENESULFONAMIDE'>5XE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fg6 OCA], [https://pdbe.org/5fg6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fg6 RCSB], [https://www.ebi.ac.uk/pdbsum/5fg6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fg6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Fedorov | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Bountra C]] |
| - | [[Category: | + | [[Category: Chaikuad A]] |
| - | [[Category: | + | [[Category: Edwards AM]] |
| - | [[Category: | + | [[Category: Fedorov O]] |
| - | [[Category: | + | [[Category: Filippakopoulos P]] |
| - | [[Category: | + | [[Category: Gerstenberger BS]] |
| - | [[Category: | + | [[Category: Knapp S]] |
| - | [[Category: Tallant | + | [[Category: Muller S]] |
| - | [[Category: | + | [[Category: Nunez-Alonso G]] |
| + | [[Category: Owen DR]] | ||
| + | [[Category: Savitsky P]] | ||
| + | [[Category: Tallant C]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal structure of the bromodomain of human BRD1 (BRPF2) in complex with OF-1 chemical probe
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Chaikuad A | Edwards AM | Fedorov O | Filippakopoulos P | Gerstenberger BS | Knapp S | Muller S | Nunez-Alonso G | Owen DR | Savitsky P | Tallant C | Von Delft F
