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Nitroreductase
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== Structural highlights == | == Structural highlights == | ||
NR <scene name='48/489319/Cv/4'>cofactor FMN is bound directly to one subunit</scene> while the <scene name='48/489319/Cv/5'>ligand - nicotinic acid - interacts with both subunits</scene>. Water molecules are shown as red spheres. | NR <scene name='48/489319/Cv/4'>cofactor FMN is bound directly to one subunit</scene> while the <scene name='48/489319/Cv/5'>ligand - nicotinic acid - interacts with both subunits</scene>. Water molecules are shown as red spheres. | ||
| - | + | ==3D structures of nitroreductase== | |
| + | [[Nitroreductase 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
| - | ==3D structures of nitroreductase== | ||
| - | |||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *Nitroreductase | ||
| - | |||
| - | **[[1f5v ]], [[1oo5]] – EcNR + FMN – ''Escherichia coli''<br /> | ||
| - | **[[3x21]], [[3x22]] – EcNR (mutant) + FMN<br /> | ||
| - | **[[3bm1]], [[1ds7]] – EcNR minimal + FMN<br /> | ||
| - | **[[3bm2]] – EcNR minimal -FMN<br /> | ||
| - | **[[1nec]], [[1kqd]] – EclNR + FMN – ''Enterobacter cloacae''<br /> | ||
| - | **[[1ywq]], [[2i7h]] – NR + FMN – ''Bacillus cereus''<br /> | ||
| - | **[[5hdj]] – NR + FMN – ''Bacillus megaterium''<br /> | ||
| - | **[[2b67]] – NR + FMN – ''Streptococcus pneumonia''<br /> | ||
| - | **[[3ek3]], [[3hoi]] – NR + FMN – ''Bacterioides fragilis''<br /> | ||
| - | **[[3g14]] – NR – ''Clostridium novyi''<br /> | ||
| - | **[[3h4o]], [[3koq]] - NR + FMN – ''Clostridium difficile''<br /> | ||
| - | **[[3gr3]] – NR + FMN – ''Bartonella henselae''<br /> | ||
| - | **[[3hzn]] – NR – ''Salmonella typhimurium''<br /> | ||
| - | **[[3k6h]] – NR + FMN – ''Agrobacterium tumefaciens''<br /> | ||
| - | **[[2wzv]], [[2ymv]] – MsNR + FMN – ''Mycobacterium smegmatis''<br /> | ||
| - | **[[3of4]] – NR + FMN + FAD – ''Idiomarina loihiensis''<br /> | ||
| - | **[[3n2s]] – NR + FMN – ''Bacillus subtilis''<br /> | ||
| - | **[[3pxv]] – NR + FMN – ''Desulfitobacterium hafniense''<br /> | ||
| - | **[[3qdl]] – NR + FMN – ''Helicobacter pylori''<br /> | ||
| - | **[[3r5l]], [[3r5p]] - MtNR – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[3ge6]] – NR + FMN – ''Exiguobacterium sibiricum''<br /> | ||
| - | **[[4dn2]] – NR + FMN – ''Geobacter metallireducens''<br /> | ||
| - | **[[5ko7]], [[5ko8]], [[5krd]] – NR + FMN – ''Haliscomenobacter hydrossis''<br /> | ||
| - | **[[7dp0]] – SpNR + FMN – ''Sphingopyxis''<br /> | ||
| - | **[[7dp1]], [[7dp2]] – SpNR (mutant) + FMN <br /> | ||
| - | **[[6czp]] – NR + FMN – ''Vibrio vulnificus''<br /> | ||
| - | |||
| - | *Copper-induced nitroreductase | ||
| - | |||
| - | **[[2wqf]] – LlNR + FMN – ''Lactococcus lactis''<br /> | ||
| - | **[[4bn6]] – LlNR + FMN + chloramphenicol<br /> | ||
| - | **[[4bn7]], [[4bn8]] – LlNR + FMN + phenol derivative<br /> | ||
| - | **[[4bn9]] – LlNR + FMN + nicotinic acid<br /> | ||
| - | **[[4bnb]] – LlNR + FMN + nitroquinoline<br /> | ||
| - | |||
| - | *Nitrobenzoate nitroreductase | ||
| - | |||
| - | **[[4z85]] – NR – ''Psudomonas fluorescens''<br /> | ||
| - | |||
| - | *Nitroreductase complex | ||
| - | **[[1kqb]], [[5j8g]]– EclNR + FMN + benzoate derivative<br /> | ||
| - | **[[1kqc]] – EclNR + FMN + acetate<br /> | ||
| - | **[[1ylr]], [[1ylu]] - EcNR + FMN + acetate<br /> | ||
| - | **[[1icr]], [[1icu]], [[1icv]], [[5j8d]] – EcNR + FMN + NAD derivative<br /> | ||
| - | **[[1ooq]] – EcNR + FMN + dicoumarol<br /> | ||
| - | **[[1oo6]], [[1oon]], [[1idt]] – EcNR + FMN + benzamide derivative<br /> | ||
| - | **[[1yki]] – EcNR + FMN + antibiotic<br /> | ||
| - | **[[7nb9]] – EcNR + FMN + nitrofurantoin<br /> | ||
| - | **[[7nmp]], [[7nnx]] – EcNR + FMN + quinone derivative<br /> | ||
| - | **[[7niy]] – EcNR (mutant) + FMN + imidazole<br /> | ||
| - | **[[2wzw]] - MsNR + FMN + NADPH<br /> | ||
| - | **[[6czp]] – NR + FMN – ''Vibrio vulnificus''<br /> | ||
| - | **[[3r5r]], [[3r5w]] – MtNR F420<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Lovering AL, Hyde EI, Searle PF, White SA. The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution. J Mol Biol. 2001 May 25;309(1):203-13. PMID:11491290 doi:10.1006/jmbi.2001.4653
- ↑ Williams EM, Little RF, Mowday AM, Rich MH, Chan-Hyams JV, Copp JN, Smaill JB, Patterson AV, Ackerley DF. Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility. Biochem J. 2015 Oct 15;471(2):131-53. doi: 10.1042/BJ20150650. PMID:26431849 doi:http://dx.doi.org/10.1042/BJ20150650
