3n4m
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==E. coli RNA polymerase alpha subunit C-terminal domain in complex with CAP and DNA== | |
| + | <StructureSection load='3n4m' size='340' side='right'caption='[[3n4m]], [[Resolution|resolution]] 2.99Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3n4m]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N4M FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.987Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n4m OCA], [https://pdbe.org/3n4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n4m RCSB], [https://www.ebi.ac.uk/pdbsum/3n4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n4m ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]] | |
| - | + | *[[RNA polymerase 3D structures|RNA polymerase 3D structures]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli K-12]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Birktoft JJ]] | ||
| + | [[Category: Lara-Gonzalez S]] | ||
| + | [[Category: Lawson CL]] | ||
Current revision
E. coli RNA polymerase alpha subunit C-terminal domain in complex with CAP and DNA
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