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3n4m

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[[Image:3n4m.jpg|left|200px]]
 
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==E. coli RNA polymerase alpha subunit C-terminal domain in complex with CAP and DNA==
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The line below this paragraph, containing "STRUCTURE_3n4m", creates the "Structure Box" on the page.
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<StructureSection load='3n4m' size='340' side='right'caption='[[3n4m]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3n4m]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N4M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.987&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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{{STRUCTURE_3n4m| PDB=3n4m | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n4m OCA], [https://pdbe.org/3n4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n4m RCSB], [https://www.ebi.ac.uk/pdbsum/3n4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n4m ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref>
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===E. coli RNA polymerase alpha subunit C-terminal domain in complex with CAP and DNA===
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==See Also==
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*[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]]
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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==About this Structure==
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== References ==
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[[3n4m]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N4M OCA].
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<references/>
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[[Category: DNA-directed RNA polymerase]]
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__TOC__
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[[Category: Escherichia coli]]
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</StructureSection>
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[[Category: Birktoft, J J.]]
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[[Category: Escherichia coli K-12]]
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[[Category: Lara-Gonzalez, S.]]
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[[Category: Large Structures]]
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[[Category: Lawson, C L.]]
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[[Category: Birktoft JJ]]
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[[Category: Lara-Gonzalez S]]
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[[Category: Lawson CL]]

Current revision

E. coli RNA polymerase alpha subunit C-terminal domain in complex with CAP and DNA

PDB ID 3n4m

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