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5ldh

From Proteopedia

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[[Image:5ldh.gif|left|200px]]
 
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{{Structure
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==STRUCTURE OF THE ACTIVE TERNARY COMPLEX OF PIG HEART LACTATE DEHYDROGENASE WITH S-LAC-NAD AT 2.7 ANGSTROMS RESOLUTION==
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|PDB= 5ldh |SIZE=350|CAPTION= <scene name='initialview01'>5ldh</scene>, resolution 2.7&Aring;
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<StructureSection load='5ldh' size='340' side='right'caption='[[5ldh]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=LNC:(3S)-5-(3-CARBOXY-3-HYDROXYPROPYL)+NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>LNC</scene>
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<table><tr><td colspan='2'>[[5ldh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LDH FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=LNC:(3S)-5-(3-CARBOXY-3-HYDROXYPROPYL)+NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>LNC</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ldh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ldh OCA], [https://pdbe.org/5ldh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ldh RCSB], [https://www.ebi.ac.uk/pdbsum/5ldh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ldh ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ldh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ldh OCA], [http://www.ebi.ac.uk/pdbsum/5ldh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=5ldh RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/LDHB_PIG LDHB_PIG]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ld/5ldh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=5ldh ConSurf].
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<div style="clear:both"></div>
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'''STRUCTURE OF THE ACTIVE TERNARY COMPLEX OF PIG HEART LACTATE DEHYDROGENASE WITH S-LAC-NAD AT 2.7 ANGSTROMS RESOLUTION'''
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==See Also==
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*[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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5LDH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LDH OCA].
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[[Category: Large Structures]]
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==Reference==
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Structure of the active ternary complex of pig heart lactate dehydrogenase with S-lac-NAD at 2.7 A resolution., Grau UM, Trommer WE, Rossmann MG, J Mol Biol. 1981 Sep 15;151(2):289-307. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7338899 7338899]
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[[Category: L-lactate dehydrogenase]]
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[[Category: Single protein]]
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Grau, U M.]]
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[[Category: Grau UM]]
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[[Category: Rossmann, M G.]]
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[[Category: Rossmann MG]]
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[[Category: choh donor]]
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[[Category: nad acceptr]]
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[[Category: oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:41:46 2008''
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Current revision

STRUCTURE OF THE ACTIVE TERNARY COMPLEX OF PIG HEART LACTATE DEHYDROGENASE WITH S-LAC-NAD AT 2.7 ANGSTROMS RESOLUTION

PDB ID 5ldh

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