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7du4
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7du4 is ON HOLD until Jan 08 2023 Authors: Xie, W., Chen, R. Description: The structure of the M.tb MazF-mt9 toxin in complex with a fragment of co...) |
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The structure of the M.tb MazF-mt9 toxin in complex with a fragment of cognate antitoxin== |
| - | + | <StructureSection load='7du4' size='340' side='right'caption='[[7du4]], [[Resolution|resolution]] 2.18Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7du4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DU4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7du4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7du4 OCA], [https://pdbe.org/7du4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7du4 RCSB], [https://www.ebi.ac.uk/pdbsum/7du4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7du4 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Chen | + | == Function == |
| + | [https://www.uniprot.org/uniprot/MAZF7_MYCTU MAZF7_MYCTU] Toxic component of a type II toxin-antitoxin (TA) module. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE7 (PubMed:19016878, PubMed:20011113). Probably an endoribonuclease (By similarity).[UniProtKB:P9WIH9]<ref>PMID:19016878</ref> <ref>PMID:20011113</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
| + | [[Category: Chen R]] | ||
| + | [[Category: Xie W]] | ||
Current revision
The structure of the M.tb MazF-mt9 toxin in complex with a fragment of cognate antitoxin
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