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2dde

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[[Image:2dde.png|left|200px]]
 
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==Structure of cinnamycin complexed with lysophosphatidylethanolamine==
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<StructureSection load='2dde' size='340' side='right'caption='[[2dde]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2dde]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_griseoverticillatus Streptomyces griseoverticillatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DDE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BH2:(3R)-3-HYDROXY-L-ASPARTIC+ACID'>BH2</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=LSP:(7S)-4,7-DIHYDROXY-10-OXO-3,5,9-TRIOXA-4-PHOSPHAUNDECAN-1-AMINIUM+4-OXIDE'>LSP</scene>, <scene name='pdbligand=PRD_000195:Cinnamycin'>PRD_000195</scene></td></tr>
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{{STRUCTURE_2dde| PDB=2dde | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dde OCA], [https://pdbe.org/2dde PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dde RCSB], [https://www.ebi.ac.uk/pdbsum/2dde PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dde ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CINA_STRGV CINA_STRGV] Can act as inhibitor of the enzyme phospholipase A2, and of the angiotensin-converting enzyme. Shows inhibitory activities against herpes simplex virus and immunopotentiating activities. Its antimicrobial activities are not very pronounced.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three-dimensional structure of a complex of cinnamycin, a 19-amino acid residue immunopotentiator peptide, and lysophosphatidylethanolamine was determined by 1H-NMR. The complex was cylindrical in shape, 11 A in diameter and 26 A in length, excluding the acyl chain of the phospholipid. The peptide had a hydrophobic pocket surrounded by residues Phe-7 through Ala(S)-14 to bind to the head group of the ligand. Fitting of the head group to the hydrophobic pocket was so good that other than a glycerophosphoethanolamine head group would be unable to fit the pocket. The goodness of the fitting is compatible with the strict specificity of ligand binding of the peptide.
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===Structure of cinnamycin complexed with lysophosphatidylethanolamine===
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Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR1.,Hosoda K, Ohya M, Kohno T, Maeda T, Endo S, Wakamatsu K J Biochem. 1996 Feb;119(2):226-30. PMID:8882709<ref>PMID:8882709</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2dde" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 8882709 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_8882709}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2dde]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_griseoverticillatus Streptomyces griseoverticillatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDE OCA].
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==Reference==
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<ref group="xtra">PMID:008882709</ref><references group="xtra"/>
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[[Category: Streptomyces griseoverticillatus]]
[[Category: Streptomyces griseoverticillatus]]
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[[Category: Endo, S.]]
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[[Category: Endo S]]
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[[Category: Hosoda, K.]]
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[[Category: Hosoda K]]
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[[Category: Kohno, T.]]
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[[Category: Kohno T]]
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[[Category: Maeda, T.]]
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[[Category: Maeda T]]
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[[Category: Ohya, M.]]
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[[Category: Ohya M]]
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[[Category: Wakamatsu, K.]]
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[[Category: Wakamatsu K]]
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[[Category: Antibiotic]]
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[[Category: Antimicrobial]]
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[[Category: Antitumor]]
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[[Category: Immunopotentiator]]
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[[Category: Lanthionine]]
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[[Category: Lipid binding]]
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[[Category: Phosphatidylethanolamine]]
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[[Category: Thioester]]
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Current revision

Structure of cinnamycin complexed with lysophosphatidylethanolamine

PDB ID 2dde

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